NCT07069660 · Washington University School of Medicine
Compass 3: A Novel Transition Program to Reduce Disability After Stroke
(COMPASS 3)
What this study is about
This study evaluates a program designed to help individuals transition from inpatient rehabilitation to home following an ischemic or hemorrhagic stroke. Half of the participants will receive a stroke education program while the other half will receive an environmental modifications program.
View original scientific description
This study evaluates a program designed to help individuals transition from inpatient rehabilitation to home following an ischemic or hemorrhagic stroke. Half of the participants will receive a stroke education program while the other half will receive an environmental modifications program.
Interventions
BEHAVIORAL
COMPASS
The data from the baseline assessment will be used to develop an environmental modification intervention plan. Environmental modifications will be installed before discharge if possible. Problem areas addressed are participant specific (tailored), but the process to identify and address the target area is systematic. All participants will receive identical intervention components. The standardized components include assessment, identification of problematic activities (and environmental barriers), identification of solutions for each problem, implementation of solution set selected by the participant, training, and active practice of daily activities in one's own home and community.
BEHAVIORAL
Education Program
The control group will experience the same effects of time and attention in the home but no effect on the outcome of interest.
Primary outcome measures
Admission to SNF (skilled nursing facility)
Time frame: From enrollment to 12 months post-discharge from inpatient rehabilitation facility
Date and days of admission to a skilled nursing facility
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Aged ≥55 years at the time of screening
- Acute stroke diagnosis (IS or ICH) verified by the stroke team or medical record
- Independent in activities of daily living (ADLs) prior to stroke (premorbid Modified Rankin Scale score ≤2)
- Plan to discharge to home from an IR
- Capable of giving informed consent which includes compliance with the requirements and duration of participation as listed in the Informed Consent Form (ICF).
Exclusion criteria
- Life expectancy \<6 months
- Cognitive impairment that the participant's stroke team or a research team member believes impairs their ability to provide informed consent or make reasoned choice including the interpretation of the self-rated scales
- Any communication problem that would prevent study completion
- Residence in a congregate living facility
- Not eligible for a therapeutic pass
- Residence outside of the designated catchment area (specific catchment distance to be determined by each site)
- Site investigator's judgment that the participant would not be able to complete research procedures or interventions
- Participation in another research study that in the site investigator's judgment could interfere or conflict with this research study's assessments or interventions
Where
- Columbia, Missouri
- St Louis, Missouri
Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Feb 13, 2026 · Source of record for eligibility and locations