NCT05081713 · Indiana University
Locomotor Recovery and Compensation Post-stroke (LRC)
(LRC)
What this study is about
The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke.
View original scientific description
The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation are malleable and can be altered with specific interventions in both the early and late stages post-stroke. Delineation of the time course of development and magnitude of patterns of recovery and compensation should result in alternative predictive "rules' regarding how patients early post-stroke could recovery functional and neurological function.
Interventions
BEHAVIORAL
high-intensity training focused on stepping in variable contexts
Approximately 10 weeks (\~30 sessions) of high-intensity training
Primary outcome measures
Gait speed
Time frame: 15 days post-stroke
Walking speed over 6 m
Gait speed
Time frame: 1 month
Walking speed over 6 m
Gait speed
Time frame: 2 months,
Walking speed over 6 m
Gait speed
Time frame: 4 months,
Walking speed over 6 m
Gait speed
Time frame: 6 months,
Walking speed over 6 m
Gait speed
Time frame: 9 months,
Walking speed over 6 m
Gait speed
Time frame: 12 months
Walking speed over 6 m
Walking distance
Time frame: 15 days post-stroke,
Distance covered over 6 min
Walking distance
Time frame: 1 month,
Distance covered over 6 min
Walking distance
Time frame: 2 months,
Distance covered over 6 min
Walking distance
Time frame: 4 months,
Distance covered over 6 min
Walking distance
Time frame: 6 months,
Distance covered over 6 min
Walking distance
Time frame: 9 months,
Distance covered over 6 min
Walking distance
Time frame: 12 months
Distance covered over 6 min
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- individuals early post-stroke (\<15-30 days)
- first ever stroke
- unilateral hemiparesis
- currently receiving inpatient rehabilitation
- ability to follow 1-step commands
- provision of informed consent
- medical clearance from the rehabilitation physician to participate. \\
Exclusion criteria
- uncontrolled cardiovascular, metabolic or respiratory disease that limits exercise participation (e.g., congestive heart failure, resting blood pressure \> 200/110 mmHg, uncontrolled diabetes, end-stage renal disease)
- absolute criteria for termination of exercise testing during initial and repeated ECG testing during graded exercise testing using ACSM guidelines .
- other orthopedic or neurological disorder that limited walking prior to stroke
Where
- Indianapolis, Indiana
Collaborators
Rehabilitation Hospital of Indiana, National Institute of Neurological Disorders and Stroke (NINDS)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 5, 2026 · Source of record for eligibility and locations