NCT02168088 · Scripps Translational Science Institute
Molecular Autopsy Study
What this study is about
This study seeks to incorporate genetic testing into the postmortem examination of cases of sudden unexplained death.
View original scientific description
This study seeks to incorporate genetic testing into the postmortem examination of cases of sudden unexplained death.
Primary outcome measures
Heritable causes of sudden death
Time frame: 3 years
The primary endpoint for this study is the discovery of genomic information that may help identify a potential cause of death in the index case. This information may inform living, biologically related family members of their potential risk and need for further genomic analysis.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Index case age between birth - 45 years
- Clinical presentation of sudden / unexplained death (believed to be cardiac in nature OR secondary to a massive unprovoked pulmonary embolism with no prior diagnosis of prothrombotic disease)
Exclusion criteria
- Premature death secondary to murder, suicide or external causal event
- Premature death thought secondary to known chronic comorbid medical condition
- Premature death thought secondary to end-organ failure (kidney, liver, lung) other than heart
- Previously diagnosed with hypertrophic cardiomyopathy (HCM)
- Prior myocardial infarction (regardless of stenting or bypass)
- Prior cerebrovascular accident (stroke or TIA)
- History of open heart surgery (for any reason)
- History of severe, untreated hypertensive heart disease
- History of illicit drug use
- History of heavy alcohol abuse
- History of severe pulmonary disease
- History of morbid obesity
Where
- La Jolla, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 16, 2025 · Source of record for eligibility and locations