NCT07438912 · University of Arizona
Mind After Midnight
(MaM)
What this study is about
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure.
View original scientific description
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure. Participants will be evaluated during late-night wakefulness and under conditions of both higher and lower sleep pressure. The goal of the study is to better understand the biological and behavioral mechanisms that may contribute to elevated suicide risk during nocturnal wakefulness.
Interventions
BEHAVIORAL
Sleep Pressure Manipulation
Participants undergo an experimental manipulation of homeostatic sleep pressure involving controlled wakefulness or scheduled awakening during the biological night. Mood, suicidal ideation, impulsivity, and decision-making are assessed during overnight laboratory sessions.
Primary outcome measures
Feelings of Hopelessness
Time frame: Visit 1(day 2, night 2), Visit 2 (day 2, night 2)
Total score on the BECK Hopelessness scale (BHS)
Impaired Executive Function
Time frame: Visit 1(day 2, night 2), Visit 2 (day 2, night 2)
BART total score
Negative Mood
Time frame: Visit 1(day 2, night 2), Visit 2 (day 2, night 2)
PANAS negative affect score
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age 18-55 years
- History of suicidal ideation within the past 6 months
- Habitual bedtime between 9:00 PM and 1:00 AM
- Habitual wake time between 6:00 AM and 9:00 AM
- Ability to provide informed consent
Exclusion criteria
- Current suicidal intent requiring immediate clinical intervention
- Diagnosis of a primary sleep disorder (e.g., untreated obstructive sleep apnea, narcolepsy)
- Bipolar disorder or psychotic disorder
- Substance use disorder within the past 3 months
- Use of medications that significantly affect sleep or circadian rhythms
- Night shift work or transmeridian travel within the past month
- Medical or neurological condition that would interfere with participation
Where
- Tucson, Arizona
Collaborators
National Institute of Mental Health (NIMH)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 22, 2026 · Source of record for eligibility and locations