Durham, NCNCT07434986Now EnrollingIRB Ready

Temporal Lobe Epilepsy (TLE) Clinical Trial in Durham, NC

Access cutting-edge temporal lobe epilepsy (tle) treatment through this clinical trial at a research site in Durham. Study-provided care at no cost to qualified participants.

Sponsored by Duke University

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Expert Care in Durham

Access temporal lobe epilepsy (tle) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related temporal lobe epilepsy (tle) treatment provided free

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Check if you qualify for this temporal lobe epilepsy (tle) clinical trial in Durham, NC

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Why Participate?

  • No-Cost Study Care

  • Local to Durham

    Convenient for NC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Durham site if eligible
  4. 4Begin participation

About This Temporal Lobe Epilepsy (TLE) Study in Durham

The goal of this clinical trial is to gauge whether overnight, non-invasive temporal interference (TI) stimulation aimed at the hippocampus can reduce abnormal brain activity linked to seizures and improve sleep in adults with drug-resistant temporal lobe epilepsy. The main questions are: Does overnight TI stimulation lower seizure-related EEG activity during sleep? Does overnight TI stimulation improve sleep quality and sleep patterns measured overnight in the lab? Researchers will compare each participant's nights without stimulation to nights with active stimulation, and will also look at a night after stimulation ends to see whether any changes last. Participants will: Stay in-lab for six days for overnight sleep and EEG monitoring Have one night of monitoring without stimulation Receive TI stimulation during sleep for several nights Have another night of monitoring without stimulation after the stimulation nights Complete brief questionnaires and thinking/memory tasks before and after the stimulation nights Be checked for side effects and comfort during the study and at follow-up

Sponsor: Duke University

Who Can Participate

Inclusion Criteria

Age 18 - 70 years
Diagnosis of focal drug-resistant temporal lobe epilepsy
Candidate for in-laboratory overnight monitoring with PSG and scalp EEG, with ability to comply with study procedures
Stable antiseizure medication regimen for at least 1 week prior to admission
Capacity to provide consent

Exclusion Criteria

Generalized epilepsy syndromes or primary generalized seizures
Recent status epilepticus, seizure clusters requiring emergency intervention, or other features indicating unacceptable risk for monitored participation
Uncontrolled psychiatric illness (e.g., acute psychosis, severe untreated depression with high suicide risk)
Implanted electronic or metallic devices incompatible with TI (e.g., certain pacemakers, cochlear implants) as per device manual
Severe obstructive sleep apnea requiring immediate CPAP initiation and not yet treated
Dermatologic disease at electrode sites or known contact allergy to electrode materials
Pregnancy or breastfeeding
Concurrent enrollment in other interventional neuromodulation or pharmacological trials likely to confound EEG or sleep outcomes

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Durham?

Yes, this clinical trial (NCT07434986) has an active research site in Durham, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Temporal Lobe Epilepsy (TLE) Treatment Options in Durham, NC

If you're searching for temporal lobe epilepsy (tle) treatment options in Durham, NC, this clinical trial (NCT07434986) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Durham research site is actively enrolling participants for this clinical trial. You'll receive care from experienced temporal lobe epilepsy (tle) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all temporal lobe epilepsy (tle) clinical trials near you to find additional studies recruiting in your area.

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See all epilepsy clinical trials recruiting in Durham — not just this study.

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Secure · Expert Care · Durham, NC