Pittsburgh, PANCT06100822Now EnrollingIRB Ready

Tendinopathy Clinical Trial in Pittsburgh, PA

Access cutting-edge tendinopathy treatment through this clinical trial at a research site in Pittsburgh. Study-provided care at no cost to qualified participants.

Sponsored by James Wang

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Expert Care in Pittsburgh

Access tendinopathy specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related tendinopathy treatment provided free

Apply for This Pittsburgh Location

Check if you qualify for this tendinopathy clinical trial in Pittsburgh, PA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Pittsburgh

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Pittsburgh site if eligible
  4. 4Begin participation

About This Tendinopathy Study in Pittsburgh

The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be treated with placebo tablets along with home exercise program.

Sponsor: James Wang

Who Can Participate

Inclusion Criteria

Willing and able to provide informed consent for participation
Clinical diagnosis of Achilles tendinopathy
Pain disability index score of between 20 - 70 points (0-100 scale VISA-A)
Sonopalpation tenderness with tendon thickening and/or loss of fibrillary architecture.
Ability to read, speak, and understand English

Exclusion Criteria

Any intervention (corticosteroids or other orthobiologic intervention as injection) to targeted tissue within the last 6 months.
Previous Achilles tendon surgery.
Known platelet abnormality or hematological disorder.
Presence of other conditions that might affect the functional scale of the indexed limb.
Unwillingness to be randomized.
Body Mass Index (BMI) greater than 30.
Occult tear in the indexed tendon.
Systemic inflammatory disease.
Use of fluoroquinolone in the past 6 months.
Subjects must not be pregnant or breastfeeding, or planning to become pregnant or breastfeed during the course of the trial
Chronic kidney disease (eGFR \<60)
Diagnosis of diabetes mellitus or elevated HbA1c at screening (\> 6.5)
Unable to take an oral medication in a non crushable pill form
Taking metformin presently or within the last 6 months
History of allergy to metformin
History of lactic acidosis or elevated lactate at screening (\> 2.2)
Severe Hepatic dysfunction
Currently taking a diabetic medication such as sitagliptin, saxagliptin, linagliptin, alogliptin, sitagliptin with metformin
Currently taking a Carbonic anhydrase inhibitor such as topiramate, zonisamide, acetazolamide, dichlorphenamide, methazolamide
Currently taking cimetidine

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Pittsburgh?

Yes, this clinical trial (NCT06100822) has an active research site in Pittsburgh, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Tendinopathy Treatment Options in Pittsburgh, PA

If you're searching for tendinopathy treatment options in Pittsburgh, PA, this clinical trial (NCT06100822) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Pittsburgh research site is actively enrolling participants for this clinical trial. You'll receive care from experienced tendinopathy specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all tendinopathy clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Pittsburgh, PA