NCT06543407 · Dartmouth-Hitchcock Medical Center
Harm Reduction for Smokers With Mental Illness
What this study is about
To compare the effectiveness of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation treatment, and to examine self-regulation (using e-cigs instead of cigarettes to cope with stress/distress and self-effectiveness) as a potential mechanism for behavior change from SWITCH IT
View original scientific description
To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation treatment, and to examine self-regulation (using e-cigs instead of cigarettes to cope with stress/distress and self-efficacy) as a potential mechanism for behavior change from SWITCH IT
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 21 years or older;
- English-speaking;
- Daily smoker (at least 10 cigarettes/day);
- At least one quit attempt in the past 5 years using evidence- based pharmacotherapy or behavioral cessation support;
- Not currently interested in quitting.
Exclusion criteria
- Currently residing in a nursing home;
- Current diagnosis of Asthma;
- Cognitive impairment (score \<26 on the Telephone Interview for Cognitive Status (TICS);
- Current use of e-cigarettes (\>once a week);
- Psychiatric instability (hospitalized in the past month);
- Current AND moderate to severe substance use disorder;
- Pregnant or planning to become pregnant;
- Use of any smoked products other than cigarettes;
- Current unstable medical illness making e-cigarette unsafe (e.g., recent heart attack, cancer);
- Participation in SWITCH IT pilot study.
Where
- Louisville, Kentucky
- Providence, Rhode Island
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 15, 2026 · Source of record for eligibility and locations