NCT07571018 · Fred Hutchinson Cancer Center
A Novel Mobile Health Intervention for Improving Tobacco Cessation Among Young Adults
What this study is about
Tobacco use is the leading cause of preventable cancer deaths. Among young adults, approximately 1 in 5 use commercial nicotine and tobacco products, putting them at risk of developing nicotine addiction and long-term health effects from exposure to toxicants. Innovative approaches are needed to engage young adults in treatment, as they are less engaged in traditional treatment.
View original scientific description
Tobacco use is the leading cause of preventable cancer deaths. Among young adults, approximately 1 in 5 use commercial nicotine and tobacco products, putting them at risk of developing nicotine addiction and long-term health effects from exposure to toxicants. Innovative approaches are needed to engage young adults in treatment, as they are less engaged in traditional treatment. This clinical trial compares two versions of a mobile health intervention called Living Free from Tobacco (LiFT), designed to support nicotine and tobacco cessation among young adults. Both versions of the app are designed to motivate and support young adults to stop using nicotine and tobacco, regardless of current readiness to quit. Version A of the LiFT app (LiFT A) focuses on increasing psychological flexibility to support cessation, while Version B (LiFT B) provides educational content and resources related to tobacco use and cessation. Both versions of the program are delivered through a smartphone application and include accompanying text messages.
Interventions
OTHER
Smartphone app-based Intervention
Use LiFT A app
OTHER
Smartphone app-based Intervention
Use LiFT B app
OTHER
Communication intervention
Receive LiFT A text messages
OTHER
Communication intervention
Receive LiFT B text messages
OTHER
Survey Administration
Complete surveys
OTHER
Interview
Attend interview
OTHER
Assessment
Complete usability assessment
OTHER
Survey Administration
Complete survey
Primary outcome measures
Overall satisfaction (Pilot trial phase)
Time frame: At 3 months
Overall satisfaction with the assigned program will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Number of logins to assigned application (Pilot trial phase)
Time frame: At 3 months
Treatment utilization will include number of logins to the assigned application, determined objectively using tracking software.
Usefulness of the program (Pilot trial phase)
Time frame: At 3 months
The perceived usefulness of the assigned program will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Usefulness of text messages (Pilot trial phase)
Time frame: At 3 months
The perceived usefulness of the assigned program's text messages will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Satisfaction with perceived tailoring (Pilot trial phase)
Time frame: At 3 months
The perception that the assigned program was made for someone like the participant will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Satisfaction with guidance on how to quit (Pilot trial phase)
Time frame: At 3 months
The perception that the program clarified how to quit nicotine/tobacco when ready will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Perception that program offered a novel approach to quitting (Pilot trial phase)
Time frame: At 3 months
The perception that the program offered a new way of looking at quitting will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Perceived helpfulness for quit preparation (Pilot trial phase)
Time frame: At 3 months
The perception that the program will help with quitting if/when ready will be assessed by self-report on a 5-point Likert-type scale from "not at all" (1) to "very much" (5) and summarized by arm using means and standard deviations.
Willingness to recommend program to a friend (Pilot trial phase)
Time frame: At 3 months
Whether the respondent would recommend the program to a friend will be assessed via responses of "yes," "no," or "not sure." Responses will be categorized into a binary variable representing "yes" versus other responses (i.e.,"no" or "not sure").
Usability (Post pilot trial diary study phase)
Time frame: At completion of post pilot trial diary study phase (At Day 9)
Qualitative data from interviews, diary entries and exit interviews will be coded and analyzed using rapid inductive content analysis to extract themes. Usability data will be reported using descriptive statistics and compared against the benchmark score of 68, which represents average usability.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-identify being between 18 and 30 years of age
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must be a United States (US) resident, with a US mailing address
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must own a smartphone
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report having internet access for the interviews
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they are interested in participating in the study for themselves (versus \[vs\] someone else)
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they have not participated in one of our prior tobacco cessation studies
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they understand and agree to the conditions of compensation
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must self-report that they are not currently incarcerated
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Participants must be willing and able to complete study procedures in English
- PILOT TRIAL: Participants must self-identify being between 18 and 30 years of age
- PILOT TRIAL: Participants must currently reside in the US and anticipate continued residence for the duration of the study (3 months)
- PILOT TRIAL: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening
- PILOT TRIAL: Participants must own an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)
- PILOT TRIAL: Participants must self-report having at least weekly internet access for the next three months
- PILOT TRIAL: Participants must be willing and able to download an app to their phone and receive text messages
- PILOT TRIAL: Participants must self-report current use of a personal email account
- PILOT TRIAL: Participants must self-report current use of text messaging
- PILOT TRIAL: Participants must self-report that they are interested in participating in the study for themselves (vs someone else)
- PILOT TRIAL: Participants must self-report that they have not participated in one of our prior tobacco cessation studies
- PILOT TRIAL: Participants must self-report that they understand and agree to the conditions of compensation
- PILOT TRIAL: Participants must self-report that they are not currently incarcerated
- PILOT TRIAL: Participants must be willing to use the assigned intervention program, complete the study assessments, and complete an online consent form in English
- POST PILOT TRIAL DIARY STUDY: Participants must self-identify being between 18 and 30 years of age
- POST PILOT TRIAL DIARY STUDY: Participants must currently reside in the US
- POST PILOT TRIAL DIARY STUDY: Participants must self-report use of any (non-therapeutic) nicotine or tobacco product at least once per week in the 30 days prior to screening
- POST PILOT TRIAL DIARY STUDY: Participants must own an Android (running version 12 or higher) or iPhone (running iOS version 17 or higher, iPhone 11 or more recent)
- POST PILOT TRIAL DIARY STUDY: Participants must self-report having at least internet access for the duration of the diary study
- POST PILOT TRIAL DIARY STUDY: Participants must be willing and able to download an app to their phone and receive text messages
- POST PILOT TRIAL DIARY STUDY: Participants must self-report current use of a personal email account
- POST PILOT TRIAL DIARY STUDY: Participants must self-report current use of text messaging
- POST PILOT TRIAL DIARY STUDY: Participants must self-report that they are interested in participating in the study for themselves (vs someone else)
- POST PILOT TRIAL DIARY STUDY: Participants must self-report that they have not participated in one of our prior tobacco cessation studies
- POST PILOT TRIAL DIARY STUDY: Participants must self-report that they understand and agree to the conditions of compensation
- POST PILOT TRIAL DIARY STUDY: Participants must self-report that they are not currently incarcerated
- POST PILOT TRIAL DIARY STUDY: Participants must be willing to use the intervention program, complete the study assessments, and complete an online consent form in English
Exclusion criteria
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals must not be \< 18 or \> 30 years of age
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals must not have a Google voice number as their sole phone number
- USER-CENTERED DESIGN AND PROGRAM DEVELOPMENT: Individuals who are non-English speaking cannot participate, as this would prevent their participation in the interviews, which will be conducted in English
- PILOT TRIAL: Participants must not be \< 18 or \> 30 years of age
- PILOT TRIAL: Participants must not be currently using other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (but initiating these treatments during the study is allowed)
- PILOT TRIAL: Participants must not be a member of the same household as another research participant
- PILOT TRIAL: Participants must not have a Google voice number as their sole phone number
- PILOT TRIAL: Participants must not be identified as fraudulent per our fraud prevention protocol
- PILOT TRIAL: Participants must not be pregnant or plan on becoming pregnant over the next 3 months
- POST PILOT TRIAL DIARY STUDY: Individuals must not be \< 18 or \> 30 years of age
- POST PILOT TRIAL DIARY STUDY: Participants must not have a Google voice number as their sole phone number
- POST PILOT TRIAL DIARY STUDY: Individuals who are non-English speaking cannot participate, as this would prevent their participation in the interviews, which will be conducted in English
Where
- Las Cruces, New Mexico
- Seattle, Washington
Collaborators
National Cancer Institute (NCI)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 23, 2026 · Source of record for eligibility and locations