Is NCT07695454 recruiting in Cleveland, OH?

Yes, NCT07695454 is currently recruiting participants at its Cleveland, OH location. This type 2 diabetes clinical trial is actively enrolling qualified participants.

How do I join the type 2 diabetes clinical trial in Cleveland?

To join this clinical trial in Cleveland, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Cleveland clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Type 2 Diabetes Clinical Trial in Cleveland, OH

About This Type 2 Diabetes Study in Cleveland

In this preliminary observation study, the investigators will assess muscle function in terms of muscle strength and leverage imaging (MRI) and spectroscopy (31P-MRS) based techniques to assess longitudinal changes in muscle volume, quality and metabolic function in patients with T2D and obesity prescribed to semaglutide therapy. The patients will be evaluated at three time points: 1) baseline, 2) 3-month and 3) 6-month after the therapy. These longitudinal changes will then be compared and correlated with changes in physical measurements such as BMI and patient reported outcome measures (PROMs). The primary aim of our study is to investigate the longitudinal effects of semaglutide therapy on patients with T2D and obesity, on skeletal muscle strength, muscle volume, quality and metabolic function.

Sponsor: The Cleveland Clinic

Who Can Participate

Inclusion Criteria

Gender: men and women

Ethnicity: all ethnic groups

Age between 45 and 75 years

BMI ≥ 30 kg/m2 and BMI \< 45 kg/m2

Diagnosis of Type 2 Diabetes (T2D) with HbA1c levels between 7% and 10.5%.

Starting subcutaneous semaglutide for clinically indicated T2D management.

Ability and willingness to participate in the study for its full duration.

Provision of informed consent for participation in research.

Exclusion Criteria

Previous intolerance or allergy to any semaglutide-based therapy.

History of prior intolerance to any GLP-1RA or GIP/GLP-1RA.

Unwillingness or uncertainty to commit to the duration of the study.

Contraindication to MRI (e.g. claustrophobia, implanted devices including cardiac pacemaker and cardioverter-defibrillators), circumference of largest calf \> 17inch/43cm (max size to fit into the MR coil).

History of myocardial infarction or coronary revascularization (percutaneous intervention or coronary artery bypass) within 30 days prior to screening.

History of hospitalization for heart failure within the past 30 days, or NYHA class IV

Current use of glucocorticoid therapy (≥5 mg prednisone or equivalent).

Self-reported weight loss \> 10 lbs in the 90 days prior to screening.

Use of other mediation, on or off-label, for the primary intent of weight loss within 90 days prior to screening.

Secondary etiologies for sarcopenia (e.g., gastrointestinal malabsorption, myopathies, severe neurological conditions).

Glomerular Filtration Rate (eGFR) within the past 120 days is not available.

Mental incapacity or language barriers preventing informed consent and compliance.

Pregnancy, plans for pregnancy in the next 12 months, or lactating/nursing females.

History of bariatric or metabolic surgery or related procedures.

Prior participation in the Endocrinology and Metabolism Institute's Integrated Weight Management Program within the past 3 months.

Active smoking.

Excessive alcohol consumption, defined as ≥3 drinks per day.

Uncontrolled lung disease (e.g., severe asthma or COPD).

Uncontrolled thyroid disease.

Personal commitments that may limit optimal participation (e.g., work, travel, caregiving responsibilities).

History of malabsorptive disorders, such as celiac disease or Crohn's disease.

Cholestatic liver disease or inadequate hepatic function (AST/ALT \> 3.0 x ULN).

Liver cirrhosis.

Conductive implanted devices (e.g., cardiac pacemaker, cardioverter-defibrillators).

Major surgical procedures or significant traumatic injury within 30 days prior to the enrollment date.

Any medical or surgical condition that, in the opinion of the principal investigator, may make the participant unfit for the trial (e.g., psychiatric disorders, malignancy).

Any condition, unwillingness, or inability, not otherwise covered by exclusion criteria, which might jeopardize the subject's safety or compliance with the protocol.

Presence of metal in the eye

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT07695454) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Type 2 Diabetes Treatment Options in Cleveland, OH

If you're searching for type 2 diabetes treatment options in Cleveland, OH, this clinical trial (NCT07695454) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced type 2 diabetes specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all type 2 diabetes clinical trials near you to find additional studies recruiting in your area.

Type 2 Diabetes Clinical Trial in Cleveland, OH

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