NCT05665244 · University of Texas Southwestern Medical Center
Laryngeal Cryotherapy for Refractory Neurogenic Cough
What this study is about
This study aims to evaluate the safety and effectiveness of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a forward-looking pilot study with a validated patient reported outcome measure
View original scientific description
This study aims to evaluate the safety and efficacy of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a prospective pilot study with a validated patient reported outcome measure
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adult patients 18 years or older with diagnosis of neurogenic cough
- Neurogenic cough is a diagnosis of
Exclusion criteria
- applied to persistent cough (8 weeks or longer)
- Negative workup for other causes, including sinonasal allergies/chronic sinusitis, cough-variant asthma, and GERD
- Patient willing to participate in a clinical trial Exclusion Criteria:
- Uncontrolled reflux (scoring on Reflux Symptom index of 13 or higher)
- Vocal fold abnormalities or impairment
- History of asthma or other underlying lung condition not adequately treated or controlled
- Uncontrolled Allergic Rhinitis (Total Nasal Symptom Score \>6, which would indicate moderate disease32)
- Reported symptom of postnasal drip
- Current smoker
- Current neuromodulator medication use
- Patient unwilling to participate in clinical trial or sign an informed consent
- End stage medical disease with poor life expectancy
- Medical instability deemed by the investigators as a contraindication for enrollment
- Abnormal Chest X-ray
- Abnormal pulmonary function testing (PFTs)
- Positive local allergy panel (combined RAST testing)
Where
- Dallas, Texas
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 30, 2026 · Source of record for eligibility and locations