NCT05953233 · Massachusetts General Hospital
School Inner City Air Study
What this study is about
The goal of this randomly assigned clinical trial is to test the effectiveness of high efficiency particulate air (HEPA) cleaners in reducing respiratory viral exposure and infections in elementary school classrooms. Classrooms will be randomly assigned to active vs. sham HEPA cleaners.
View original scientific description
The goal of this randomized clinical trial is to test the efficacy of high efficiency particulate air (HEPA) cleaners in reducing respiratory viral exposure and infections in elementary school classrooms. Classrooms will be randomized to active vs. sham HEPA cleaners.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Grades K-5 (age 6-12 years)
- Attend one of the schools that the study team has permission to obtain classroom/school environmental samples
- Have no plans to move schools within the upcoming 12 months
- Subject and/or parent guardian must be able to understand and provide informed consent and also willing to participate in the study Adults
- Adult (age 21 or older) parent, caretaker, or household member of child participating in this study, or teacher in classroom participating in study
- Able to understand and provide informed consent
Exclusion criteria
- Contraindication to or inability to participate in home self-collection of nasal swab samples
- Severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility)
- Severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance
- Families who do not speak English or Spanish well enough to complete the survey questions, as validated versions in other languages are not available for all of the measures Adults
- Contraindication to or inability to participate in home self-collection of nasal swab samples
- Severe chronic diseases (e.g. cancer, genetic or congenital disorders interfering with mobility)
- Severe neurobehavioral, neurodevelopmental or psychiatric disorders requiring special assistance
- Families who do not speak English or Spanish well enough to complete the survey questions, as validated versions in other languages are not available for all of the measures
Where
- Boston, Massachusetts
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Dec 11, 2025 · Source of record for eligibility and locations