NCT05418244 · State University of New York at Buffalo
Inhaled Isopropyl Alcohol for Treatment of Nausea
What this study is about
To determine the effectiveness of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.
View original scientific description
To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.
Interventions
OTHER
Inhaled Isopropyl Alcohol
Isopropyl alcohol pad (Covidien Webcol 2 ply prep pads, saturated with 70% isopropyl alcohol) held 1-2 cm under the subject's nares
DRUG
Oral Ondansetron
4 mg oral disintegrating ondansetron tablet once
OTHER
Inhaled Placebo
Normal saline pad (Hygea sterile saline wipe) held 1-2 cm under the subject's nares
Primary outcome measures
Change in Nausea Score at 30 Minutes
Time frame: 30 minutes post-intervention as compared to baseline
Baxter Animated Retching Faces nausea score, 0-10 with higher score meaning worse nausea
Change in Nausea Score at 10 Minutes
Time frame: 10 minutes post-interventnon as compared to baseline
Baxter Animated Retching Faces nausea score, 0-10 with higher score meaning worse nausea
Change in Nausea Score at Discharge
Time frame: At ED discharge (assessed up to 10 hours) as compared to baseline
Baxter Animated Retching Faces nausea score, 0-10 with higher score meaning worse nausea
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patients with a chief complaint of nausea or vomiting
- Ages 7-178 years, both sexes
- Weight ≥ 15 kg
- Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10
Exclusion criteria
- 1\. Require IV access
- Inability to breathe in/out through the nose
- Anosmia (self- or parental report)
- Allergy to isopropyl alcohol or ondansetron
- Current or history of alcohol abuse
- Inability to communicate feeling nauseous
- Inability to follow directions regarding taking deep breaths through the nose
- Known prolonged QT interval
- Received antiemetics within the last 8 hours
- Currently taking apomorphine
Where
- Buffalo, New York
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 8, 2025 · Source of record for eligibility and locations