NCT07674680 · University of Missouri-Columbia
Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women
What this study is about
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
View original scientific description
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
Interventions
DRUG
Placebo
Participants will receive a placebo in pill form.
DRUG
Gemtesa
Participants will receive oral gemtesa (75 mg).
Primary outcome measures
Blood flow
Time frame: Change from baseline to minute 2.
Blood flow measured with Doppler ultrasound.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Healthy women,
- Assigned female at birth,
- 18-70 years of age,
- Body mass index \<18 or ≥30 kg/m2,
Exclusion criteria
- Assigned male at birth,
- Breastfeeding,
- History of hormone replacement therapy, chemical menopause, or oophor-ectomy
- Polycystic ovarian syndrome or Primary ovarian insufficiency,
- Current smoking/Nicotine use,
- Blood pressure ≥140/90 mmHg,
- Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy,
- Nerve/neurologic disease,
- Cardiovascular, hepatic, renal, respiratory disease,
- Hypersensitivity to nitroglycerin,
- Communication barriers,
Where
- Columbia, Missouri
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Sep 10, 2026 · Source of record for eligibility and locations