Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
Acne is common illness of adolescents and young adults which is associated with substantial morbidity. While topical treatments are often sufficient for mild acne, moderate to severe acne often requir...
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
The purpose of the trial is to evaluate the safety, efficacy and immunogenicity of up to 3 intramuscular injections of the Acne mRNA vaccine candidate at up to three dose levels in adult participants ...
Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors
The goal of this clinical trial is to learn about HT-001 Topical Gel for treatment of EGFR inhibitor-induced skin toxicities. The main questions it aims to answer are: * Determine the therapeutic eff...
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Participants With Mild Acne
The purpose of the VBE00009 study is to evaluate the safety, efficacy and immunogenicity of 2 administrations of the Acne mRNA vaccine candidate at single dose level in participants aged 18 to 45 year...
LUT014 for the Reduction of Dose-Limiting Acneiform Lesions Associated With EGFRI Treatment of mCRC
The study evaluates the efficacy and safety of two strengths of LUT014 Gel topically applied once a day for 4 weeks, compared to placebo, in metastatic colorectal cancer (mCRC) patients who developed ...
Top Cities for Acne Clinical Trials
Acne clinical trials are recruiting across 35 cities. Here are the cities with the most active studies:
About Acne
Acne is a common skin condition that occurs when hair follicles become clogged with oil and dead skin cells, causing pimples, blackheads, and cysts. It affects up to 85% of people between ages 12-24. Treatment includes topical and oral medications, hormonal therapy, and isotretinoin for severe cases.
Clinical trials are advancing new treatments for acne. Currently, 5 studies are recruiting a combined 999 participants across the United States. Research is being conducted by 4 organizations including University of Pennsylvania, Sanofi Pasteur, a Sanofi Company, Hoth Therapeutics, Inc. and 1 others.
2026 Acne Research Landscape
As of March 2026, the acne clinical trial landscape includes 5 actively recruiting studies across 35 cities in the United States. These studies are collectively seeking 999 participants, with an average enrollment target of 200 per study.
Research is being led by 4 different organizations, including University of Pennsylvania, Sanofi Pasteur, a Sanofi Company, Hoth Therapeutics, Inc., Lutris Pharma Ltd..
Geographically, acne trials are most concentrated in Miami, Florida (4 trials); Boston, Massachusetts (3 trials); New York, New York (2 trials); Encino, California (2 trials); Fort Smith, Arkansas (1 trial) and 7 other cities.
Featured Acne Studies
Highlighted recruiting studies for acne, selected by enrollment size and research scope.
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
Acne is common illness of adolescents and young adults which is associated with substantial morbidity. While topical treatments are often sufficient for mild acne, moderate to severe acne often requires treatment with systemic medications such as oral antibiotics, hormonal therapies such spironolactone, and isotretinoin. Sebum overproduction is fundamental to the pathogenesis of acne with associat...
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
The purpose of the trial is to evaluate the safety, efficacy and immunogenicity of up to 3 intramuscular injections of the Acne mRNA vaccine candidate at up to three dose levels in adult participants aged 18 to 45 years with moderate to severe acne. This trial will consist of a Core Study followed by an optional Long-Term Extension (LTE). The Core Study will consist of a Sentinel Cohort A paired ...
Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors
The goal of this clinical trial is to learn about HT-001 Topical Gel for treatment of EGFR inhibitor-induced skin toxicities. The main questions it aims to answer are: * Determine the therapeutic effect of HT-001 for treatment of patients who develop acneiform rash undergoing Epidermal Growth Factor inhibitor (EGFRI) therapy using the acneiform rash investigator's global assessment scale \[ARIGA\...
Frequently Asked Questions About Acne Clinical Trials
Are there acne clinical trials near me?
Yes, there are 5 acne clinical trials currently recruiting across 35+ cities in the United States, including Miami, Florida; Boston, Massachusetts; New York, New York. Browse the studies above to find one at a location convenient for you.
How do I join a acne clinical trial?
To join a acne clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are acne clinical trials free?
Yes, participation in acne clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of acne treatments are being studied?
Current acne clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 4 research organizations.
Is it safe to participate in acne clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 2, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 2, 2026 · Data from ClinicalTrials.gov