A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations....
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition t...
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breat...
Top Cities for Moderate-to-Severe Asthma Clinical Trials
Moderate-to-Severe Asthma clinical trials are recruiting across 23 cities. Here are the cities with the most active studies:
About Moderate-to-Severe Asthma
Moderate-to-severe asthma affects patients whose symptoms are not adequately controlled with standard inhaled therapies. It accounts for 5-10% of asthma patients but drives a disproportionate share of healthcare costs. Biologic therapies targeting specific inflammatory pathways have transformed management.
Clinical trials are advancing new treatments for moderate-to-severe asthma. Currently, 3 studies are recruiting a combined 930 participants across the United States. Research is being conducted by 3 organizations including Amgen, Pfizer, Regeneron Pharmaceuticals.
2026 Moderate-to-Severe Asthma Research Landscape
As of March 2026, the moderate-to-severe asthma clinical trial landscape includes 3 actively recruiting studies across 23 cities in the United States. These studies are collectively seeking 930 participants, with an average enrollment target of 310 per study.
Research is being led by 3 different organizations, including Amgen, Pfizer, Regeneron Pharmaceuticals.
Geographically, moderate-to-severe asthma trials are most concentrated in Lancaster, California (3 trials); Bakersfield, California (2 trials); La Jolla, California (2 trials); Newport Beach, California (2 trials); Orange, California (2 trials) and 7 other cities.
Featured Moderate-to-Severe Asthma Studies
Highlighted recruiting studies for moderate-to-severe asthma, selected by enrollment size and research scope.
A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations.
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have ...
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breathe. Uncontrolled asthma means that patients are still having frequent symptoms while taking their current asthma medication. The aim of the study is to see which regimen is more effective: taking dup...
Frequently Asked Questions About Moderate-to-Severe Asthma Clinical Trials
Are there moderate-to-severe asthma clinical trials near me?
Yes, there are 3 moderate-to-severe asthma clinical trials currently recruiting across 23+ cities in the United States, including Lancaster, California; Bakersfield, California; La Jolla, California. Browse the studies above to find one at a location convenient for you.
How do I join a moderate-to-severe asthma clinical trial?
To join a moderate-to-severe asthma clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are moderate-to-severe asthma clinical trials free?
Yes, participation in moderate-to-severe asthma clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of moderate-to-severe asthma treatments are being studied?
Current moderate-to-severe asthma clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 3 research organizations.
Is it safe to participate in moderate-to-severe asthma clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov