14 Depression Clinical Trials in Atlanta, GA (2026)

Q: How do I join a clinical trial in Atlanta?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Atlanta research site will contact you.

Recruiting Depression Studies in Atlanta

NCT04099056Recruiting

Brain Stimulation and Decision-making

Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in ...

Atlanta, GANA500 participantsEmory University

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NCT05850689Recruiting

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

This is a multicenter, randomized, double-blind, placebo-controlled parallel-group, fixed-dose study in patients with a primary diagnosis of MDD according to criteria of the Diagnostic and Statistical...

Atlanta, GAPHASE3470 participantsIntra-Cellular Therapies, Inc.

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NCT06725277Recruiting

The OBSERVE Protocol

This observational protocol is intended to provide long-term follow-up data on patients initiating or continuing treatment with either Spravato® or IV ketamine. This can provide us information on the ...

Atlanta, GA450 participantsYale University

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NCT06713616Recruiting

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for us...

Atlanta, GAPHASE3400 participantsYale University

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NCT07300969Recruiting

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

The goal of this clinical trial is to learn if DT-101 can treat depression in adults. The effect of DT-101 will be compared to placebo. Subjects will attend the clinic every couple of weeks complete g...

Atlanta, GAPHASE2300 participantsDraig Therapeutics Ltd

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NCT06911112Recruiting

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

Atlanta, GAPHASE3200 participantsNeurocrine Biosciences

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NCT07592689Recruiting

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend...

Atlanta, GAPHASE3165 participantsDefinium Therapeutics US, Inc.

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NCT05327699Recruiting

Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine

The main purpose of this study is to investigate the effects of ketamine on decision-making and emotion processing in a sample of individuals diagnosed with Major Depressive Disorder (MDD)....

Atlanta, GAEARLY_PHASE1140 participantsEmory University

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NCT05548244Recruiting

Mechanisms of Behavioral Activation (BA)

The investigators will be comparing brain (neural) activation of depressed adolescent patients before, during and after a course of Behavioral Activation (BA) therapy using functional magnetic resonan...

Atlanta, GANA136 participantsEmory University

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NCT02604277Recruiting

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder. Additionally, the study aims to identify treatmen...

Atlanta, GANA130 participantsEmory University

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NCT07003997Recruiting

JAK Signaling in Depression

This study will test the hypothesis that Janus kinase (JAK) signaling is involved in major depression (MD) with high inflammation by determining whether its inhibition with baricitinib can improve fun...

Atlanta, GAPHASE2100 participantsEmory University

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NCT06423430Recruiting

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjuncti...

Atlanta, GANA100 participantsAbbott Medical Devices

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NCT06580145Recruiting

Leucine in Midlife Depression

The study aims to investigate the effects of a 6-week leucine challenge on brain chemistry, connectivity, and behavior in people with midlife depression. The researchers will compare the leucine and ...

Atlanta, GAPHASE275 participantsEmory University

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NCT05849038Recruiting

Inflammation and Depression in People With HIV

The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia a...

Atlanta, GAPHASE260 participantsEmory University

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About Depression Clinical Trials in Atlanta

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 14 depression clinical trials recruiting participants in Atlanta, GA. These studies are seeking a combined 3,226 participants. Research is being sponsored by Emory University, Intra-Cellular Therapies, Inc., Yale University and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Atlanta — FAQ

Are there depression clinical trials in Atlanta?

Yes, there are 14 depression clinical trials currently recruiting in Atlanta, GA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Atlanta?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Atlanta research site will contact you about next steps.

Are clinical trials in Atlanta free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Atlanta studies also compensate for your time and travel.

What depression treatments are being tested?

The 14 active trials in Atlanta are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 16, 2026 from ClinicalTrials.gov