Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Depression Clinical Trials
Depression clinical trials are recruiting across 145 cities. Here are the cities with the most active studies:
Depression Trial Phases
75 research organizations are sponsoring depression trials.
About Depression
Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.
Clinical trials are advancing new treatments for depression. Currently, 100 studies are recruiting a combined 258,179 participants across the United States. Research is being conducted by 75 organizations including Neuronetics, Adams Clinical, LivaNova and 72 others.
2026 Depression Research Landscape
As of July 2026, the depression clinical trial landscape includes 100 actively recruiting studies across 145 cities in the United States. These studies are collectively seeking 258,179 participants, with an average enrollment target of 2,582 per study.
The research spans multiple phases of development: 54 studies are in NA, 14 studies are in PHASE3, 11 studies are in PHASE2, 1 study is in EARLY_PHASE1, 1 study is in PHASE4. The presence of Phase 3 trials indicates that some depression treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 75 different organizations, including Neuronetics, Adams Clinical, LivaNova, New York University, National Institute of Mental Health (NIMH), and 70 others. The large number of sponsors reflects significant research interest and investment in depression treatment advancement.
Geographically, depression trials are most concentrated in Los Angeles, California (12 trials); San Diego, California (8 trials); Little Rock, Arkansas (8 trials); Miami, Florida (8 trials); Glendale, California (7 trials) and 7 other cities.
Featured Depression Studies
Highlighted recruiting studies for depression, selected by enrollment size and research scope.
Retrospective Analyses of TrakStar Database
In this study, real-world data will be used to better understand the effects patient characteristics, symptoms and TMS protocol parameters have on clinical outcomes with NeuroStar TMS.
Triage Survey for Psychiatry Research Eligibility
TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials.
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
The study involves multiple retrospective analyses to understand the utilization of mental health treatments provided at Greenbrook and their effectiveness
Frequently Asked Questions About Depression Clinical Trials
Are there depression clinical trials near me?
Yes, there are 100 depression clinical trials currently recruiting across 145+ cities in the United States, including Los Angeles, California; San Diego, California; Little Rock, Arkansas. Browse the studies above to find one at a location convenient for you.
How do I join a depression clinical trial?
To join a depression clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are depression clinical trials free?
Yes, participation in depression clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of depression treatments are being studied?
Current depression clinical trials are testing a range of approaches across NA (54 studies), PHASE3 (14 studies), PHASE2 (11 studies), EARLY_PHASE1 (1 study), PHASE4 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 75 research organizations.
Is it safe to participate in depression clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov