Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Bipolar Disorder Clinical Trials
Bipolar Disorder clinical trials are recruiting across 89 cities. Here are the cities with the most active studies:
Bipolar Disorder Trial Phases
36 research organizations are sponsoring bipolar disorder trials.
About Bipolar Disorder
Bipolar disorder is a mental health condition marked by extreme mood swings including emotional highs (mania or hypomania) and lows (depression). It affects about 2.8% of adults in the U.S. Treatment typically involves mood stabilizers, antipsychotics, and psychotherapy.
Clinical trials are advancing new treatments for bipolar disorder. Currently, 60 studies are recruiting a combined 32,368 participants across the United States. Research is being conducted by 36 organizations including National Institute of Mental Health (NIMH), Parnassia Groep, The University of Texas Health Science Center, Houston and 33 others.
2026 Bipolar Disorder Research Landscape
As of July 2026, the bipolar disorder clinical trial landscape includes 60 actively recruiting studies across 89 cities in the United States. These studies are collectively seeking 32,368 participants, with an average enrollment target of 539 per study.
The research spans multiple phases of development: 20 studies are in NA, 16 studies are in PHASE2, 10 studies are in PHASE3, 4 studies are in PHASE1, 1 study is in PHASE4. The presence of Phase 3 trials indicates that some bipolar disorder treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 36 different organizations, including National Institute of Mental Health (NIMH), Parnassia Groep, The University of Texas Health Science Center, Houston, Bristol-Myers Squibb, Xenon Pharmaceuticals Inc., and 31 others. The large number of sponsors reflects significant research interest and investment in bipolar disorder treatment advancement.
Geographically, bipolar disorder trials are most concentrated in Little Rock, Arkansas (11 trials); Anaheim, California (9 trials); Orange, California (9 trials); Garden Grove, California (8 trials); Culver City, California (7 trials) and 7 other cities.
Featured Bipolar Disorder Studies
Highlighted recruiting studies for bipolar disorder, selected by enrollment size and research scope.
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety o...
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
A 24-week, patient- and rater-blinded, two-arm, parallel-group controlled, and multi-centre randomized clinical trial (RCT) to establish the benefits of pharmacogenetics-informed pharmacotherapy versus dosing as usual (DAU) in psychiatric patients suffering from mood, anxiety, or psychotic disorders.
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
This study seeks to learn more about the symptoms of severe mood dysregulation in children and adolescents ages 7-17. Children and adolescents with severe mood dysregulation (SMD) display chronic anger, sadness, or irritability, as well as hyperarousal (such as insomnia, distractibility, hyperactivity) and extreme responses to frustration (such as frequent, severe temper tantrums). Researchers wil...
Frequently Asked Questions About Bipolar Disorder Clinical Trials
Are there bipolar disorder clinical trials near me?
Yes, there are 60 bipolar disorder clinical trials currently recruiting across 89+ cities in the United States, including Little Rock, Arkansas; Anaheim, California; Orange, California. Browse the studies above to find one at a location convenient for you.
How do I join a bipolar disorder clinical trial?
To join a bipolar disorder clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are bipolar disorder clinical trials free?
Yes, participation in bipolar disorder clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of bipolar disorder treatments are being studied?
Current bipolar disorder clinical trials are testing a range of approaches across NA (20 studies), PHASE2 (16 studies), PHASE3 (10 studies), PHASE1 (4 studies), PHASE4 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 36 research organizations.
Is it safe to participate in bipolar disorder clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov