National Adaptive Trial for PTSD Related Insomnia
Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of thi...
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant i...
Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia
This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female pediatric participants with...
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress
Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans...
Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder
This study assesses the efficacy, safety, and pharmacokinetics of multiple-dose oral administration of daridorexant in pediatric subjects aged 10 to \< 18 years with insomnia disorder....
Suvorexant and Sleep/Delirium in ICU Patients
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the...
Top Cities for Insomnia Clinical Trials
Insomnia clinical trials are recruiting across 32 cities. Here are the cities with the most active studies:
About Insomnia
Insomnia is a common sleep disorder characterized by difficulty falling asleep, staying asleep, or getting restful sleep. Chronic insomnia affects about 10% of adults and can impair daytime functioning. Treatment includes cognitive behavioral therapy for insomnia (CBT-I) and medications.
Clinical trials are advancing new treatments for insomnia. Currently, 6 studies are recruiting a combined 2,406 participants across the United States. Research is being conducted by 5 organizations including VA Office of Research and Development, Janssen Research & Development, LLC, Vanda Pharmaceuticals and 2 others.
2026 Insomnia Research Landscape
As of March 2026, the insomnia clinical trial landscape includes 6 actively recruiting studies across 32 cities in the United States. These studies are collectively seeking 2,406 participants, with an average enrollment target of 401 per study.
Research is being led by 5 different organizations, including VA Office of Research and Development, Janssen Research & Development, LLC, Vanda Pharmaceuticals, Idorsia Pharmaceuticals Ltd., Beth Israel Deaconess Medical Center.
Geographically, insomnia trials are most concentrated in Birmingham, Alabama (2 trials); Long Beach, California (2 trials); San Francisco, California (2 trials); West Haven, Connecticut (2 trials); Tucson, Arizona (2 trials) and 7 other cities.
Featured Insomnia Studies
Highlighted recruiting studies for insomnia, selected by enrollment size and research scope.
National Adaptive Trial for PTSD Related Insomnia
Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone or eszopiclone can help decrease symptoms of insomnia in patients with PTSD. PTSD is a form of intense anxiety which sometimes re...
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective ser...
Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia
This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female pediatric participants with insomnia disorder.
Frequently Asked Questions About Insomnia Clinical Trials
Are there insomnia clinical trials near me?
Yes, there are 6 insomnia clinical trials currently recruiting across 32+ cities in the United States, including Birmingham, Alabama; Long Beach, California; San Francisco, California. Browse the studies above to find one at a location convenient for you.
How do I join a insomnia clinical trial?
To join a insomnia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are insomnia clinical trials free?
Yes, participation in insomnia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of insomnia treatments are being studied?
Current insomnia clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 5 research organizations.
Is it safe to participate in insomnia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov