Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Insomnia Clinical Trials
Insomnia clinical trials are recruiting across 93 cities. Here are the cities with the most active studies:
Insomnia Trial Phases
56 research organizations are sponsoring insomnia trials.
About Insomnia
Insomnia is a common sleep disorder characterized by difficulty falling asleep, staying asleep, or getting restful sleep. Chronic insomnia affects about 10% of adults and can impair daytime functioning. Treatment includes cognitive behavioral therapy for insomnia (CBT-I) and medications.
Clinical trials are advancing new treatments for insomnia. Currently, 87 studies are recruiting a combined 18,236 participants across the United States. Research is being conducted by 56 organizations including University of Pennsylvania, University of Rochester, Brigham and Women's Hospital and 53 others.
2026 Insomnia Research Landscape
As of September 2026, the insomnia clinical trial landscape includes 87 actively recruiting studies across 93 cities in the United States. These studies are collectively seeking 18,236 participants, with an average enrollment target of 210 per study.
The research spans multiple phases of development: 62 studies are in NA, 7 studies are in PHASE2, 5 studies are in PHASE4, 4 studies are in PHASE3, 4 studies are in EARLY_PHASE1, 1 study is in PHASE1. The presence of Phase 3 trials indicates that some insomnia treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 56 different organizations, including University of Pennsylvania, University of Rochester, Brigham and Women's Hospital, Vanda Pharmaceuticals, University of Washington, and 51 others. The large number of sponsors reflects significant research interest and investment in insomnia treatment advancement.
Geographically, insomnia trials are most concentrated in Boston, Massachusetts (6 trials); Philadelphia, Pennsylvania (4 trials); Rochester, New York (4 trials); Pittsburgh, Pennsylvania (4 trials); Columbia, Missouri (4 trials) and 7 other cities.
Featured Insomnia Studies
Highlighted recruiting studies for insomnia, selected by enrollment size and research scope.
A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia
The purpose of this study is to assess the relative effectiveness, safety, and durability of the most commonly used prescription (zolpidem, trazodone) and over-the-counter (OTC) (melatonin, diphenhydramine) medications for insomnia, as well as a less commonly used prescription that may have a better risk/benefit profile (doxepin).
Digital CBT for Insomnia and Depression
This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depression. The first objective is to address whether sequential treatment of insomnia and depression is superior to a single treatment for either depression or for insomnia, and if so, which treatment sequence is optimal. The second objective is to ...
Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms
The goal of this clinical trial is to learn how three current insomnia therapies (trazodone, daridorexant, cognitive behavioral therapy for insomnia) compare with each other in peri- and post-menopausal women. It will also learn about the safety of the treatments. The main questions it aims to answer are: Which commonly used insomnia therapies are most effective and safe for improving insomnia sy...
Frequently Asked Questions About Insomnia Clinical Trials
Are there insomnia clinical trials near me?
Yes, there are 87 insomnia clinical trials currently recruiting across 93+ cities in the United States, including Boston, Massachusetts; Philadelphia, Pennsylvania; Rochester, New York. Browse the studies above to find one at a location convenient for you.
How do I join a insomnia clinical trial?
To join a insomnia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are insomnia clinical trials free?
Yes, participation in insomnia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of insomnia treatments are being studied?
Current insomnia clinical trials are testing a range of approaches across NA (62 studies), PHASE2 (7 studies), PHASE4 (5 studies), PHASE3 (4 studies), EARLY_PHASE1 (4 studies), PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 56 research organizations.
Is it safe to participate in insomnia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated September 3, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated September 3, 2026 · Data from ClinicalTrials.gov