Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Substance Use Disorder Clinical Trials
Substance Use Disorder clinical trials are recruiting across 109 cities. Here are the cities with the most active studies:
Substance Use Disorder Trial Phases
61 research organizations are sponsoring substance use disorder trials.
About Substance Use Disorder
Substance use disorder is a condition where the use of substances leads to health issues, disability, and failure to meet responsibilities. It encompasses alcohol, opioid, stimulant, and other drug addictions. Treatment includes behavioral therapy, medication-assisted treatment, and support programs.
Clinical trials are advancing new treatments for substance use disorder. Currently, 100 studies are recruiting a combined 317,307 participants across the United States. Research is being conducted by 61 organizations including Boston University, University of Washington, Sharon Levy and 58 others.
2026 Substance Use Disorder Research Landscape
As of July 2026, the substance use disorder clinical trial landscape includes 100 actively recruiting studies across 109 cities in the United States. These studies are collectively seeking 317,307 participants, with an average enrollment target of 3,173 per study.
The research spans multiple phases of development: 56 studies are in NA, 15 studies are in PHASE2, 12 studies are in PHASE3, 4 studies are in PHASE4, 3 studies are in PHASE1, 2 studies are in EARLY_PHASE1. The presence of Phase 3 trials indicates that some substance use disorder treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 61 different organizations, including Boston University, University of Washington, Sharon Levy, National Institute on Drug Abuse (NIDA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), and 56 others. The large number of sponsors reflects significant research interest and investment in substance use disorder treatment advancement.
Geographically, substance use disorder trials are most concentrated in Boston, Massachusetts (9 trials); New York, New York (8 trials); Baltimore, Maryland (7 trials); New Haven, Connecticut (6 trials); San Francisco, California (6 trials) and 7 other cities.
Featured Substance Use Disorder Studies
Highlighted recruiting studies for substance use disorder, selected by enrollment size and research scope.
Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic
"Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulations than medications for other substance use disorders, including medication for alcohol use disorder ...
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical services (EMS) in Seattle, WA. Those transported to the SASC are the intervention participants and two comparison groups will be utilized: eligible Seattle EMS patients wh...
Adolescent Outcomes of Post-operative Opioid EXposure
The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical patients. The main question aims to identify factors (moderators, mediators, and covariates) associated with risk factors for opioid use disorder (ROUD) in the 12 months following major surgery with o...
Frequently Asked Questions About Substance Use Disorder Clinical Trials
Are there substance use disorder clinical trials near me?
Yes, there are 100 substance use disorder clinical trials currently recruiting across 109+ cities in the United States, including Boston, Massachusetts; New York, New York; Baltimore, Maryland. Browse the studies above to find one at a location convenient for you.
How do I join a substance use disorder clinical trial?
To join a substance use disorder clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are substance use disorder clinical trials free?
Yes, participation in substance use disorder clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of substance use disorder treatments are being studied?
Current substance use disorder clinical trials are testing a range of approaches across NA (56 studies), PHASE2 (15 studies), PHASE3 (12 studies), PHASE4 (4 studies), PHASE1 (3 studies), EARLY_PHASE1 (2 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 61 research organizations.
Is it safe to participate in substance use disorder clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov