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NCT06023459RECRUITINGIRB Ready

Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)

(RXR)

Sponsored by Yih-Ing Hser

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...
๐Ÿ“Š
1 of 144 participants interested
1% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This pilot trial will explore the feasibility, acceptability, and effectiveness of the most recently approved formulation of injectable extended-release buprenorphine (XR-BUP) for treatment of opioid use disorder (OUD) in rural settings. We will randomize 144 eligible individuals with moderate to severe OUD in a 2:1 ratio to one of two medication conditions: (1) XR-BUP (128mg target), administered every 4 weeks or (2) SL-BUP (16mg-24 mg/day target).

Who Can Participate

Inclusion Criteria

Be โ‰ฅ18 years of age 2. Meet DSM-5 criteria for moderate to severe OUD or be on buprenorphine medication for OUD 3. Be interested in receiving buprenorphine treatment for OUD 4. Be willing to be randomized to either SL-BUP or XR-BUP 5. Be willing to comply with all study procedures 6. Be in good general health, as determined by the study Medical Clinician based on medical/psychiatric histories and physical exam, to permit treatment in an outpatient setting 7. If female of childbearing potential, be willing to practice an effective method of birth control for the duration of participation in the study intervention and agree to study-administered pregnancy testing during their participation in the study 8. Be able to speak English sufficiently to understand the study procedures 9. Be willing and able to provide written informed consent to participate in the study

Exclusion Criteria

Have evidence of a serious psychiatric disorder as assessed by the study Medic

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

144 participants

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Gender

ALL

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Sponsor

Yih-Ing Hser

Study Locations

Choose your preferred location or select flexible during enrollment

Unknown

El Dorado

Arkansas

Location available
View El Dorado location page
Unknown

Garberville

California

Location available
View Garberville location page
Unknown

Gibson City

Illinois

Location available
View Gibson City location page
Unknown

Belfast

Maine

Location available
View Belfast location page
Unknown

Scappoose

Oregon

Location available
View Scappoose location page
Unknown

Colville

Washington

Location available
View Colville location page
Unknown

New Martinsville

West Virginia

Location available
View New Martinsville location page

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Looking for Opioid Use Disorder Treatment in El Dorado?

Join others in Arkansas exploring innovative treatment options through clinical research

Opioid Use Disorder Treatment Options in El Dorado, Arkansas

If you're searching for Opioid Use Disorder treatment in El Dorado, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in El Dorado, Garberville, Gibson City and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Opioid Use Disorder. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Arkansas
Now Enrolling
Up to 144 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Opioid Use Disorder?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Opioid Use Disorder

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Opioid Use Disorder Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06023459. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.