16 Breast Cancer Clinical Trials in Baltimore, MD (2026)

Q: How do I join a clinical trial in Baltimore?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Baltimore research site will contact you.

Recruiting Breast Cancer Studies in Baltimore

NCT07186296Recruiting

EXoPERT EMERALD Clinical Study

The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software...

Baltimore, MD1,400 participantsEXoPERT

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NCT07340541Recruiting

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/hormone receptor-negative (ER+/HR-) and tripl...

Baltimore, MDPHASE2700 participantsUNC Lineberger Comprehensive Cancer Center

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NCT05696626Recruiting

Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

The goal of this clinical trial is to assess the efficacy, safety and tolerability of the combination of lasofoxifene and abemaciclib compared to fulvestrant and abemaciclib for the treatment of pre- ...

Baltimore, MDPHASE3600 participantsSermonix Pharmaceuticals Inc.

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NCT05386719Recruiting

Cardiometabolic Screening Program

This research study is being done to implement a screening program for prediabetes, diabetes, dyslipidemia and/or hyperlipidemia, and higher risk of cardiovascular disease in breast cancer survivors. ...

Baltimore, MDNA450 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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NCT05856773Recruiting

Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton Therapy

The purpose of this research study is to learn more about the effects of using proton radiation therapy delivered over a shorter course of treatment (3 weeks) compared with a longer, standard course o...

Baltimore, MDPHASE3276 participantsProton Collaborative Group

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NCT05780814Recruiting

The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer

The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-b...

Baltimore, MDNA250 participantsJohns Hopkins University

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NCT01766297Recruiting

Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancer

The purpose of this research study is to compare the effects (good and bad) on women and their cancer using proton radiation therapy. This study is being done to see if proton radiation therapy will ...

Baltimore, MDPHASE2132 participantsProton Collaborative Group

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NCT06764940Recruiting

A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

This study is a multicenter, two-stage clinical trial to evaluate the efficacy and safety of utidelone in combination with capecitabine in patients with HER2-negative breast cancer with brain metastas...

Baltimore, MDPHASE2120 participantsBiostar Pharma, Inc.

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NCT06568692Recruiting

A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer

This is an adaptive Phase 2, open-label, randomized, multi-center study evaluating up to 2 regimens of PCS6422 with capecitabine (Cap) vs. standard dose of Cap alone in patients with advanced or metas...

Baltimore, MDPHASE290 participantsProcessa Pharmaceuticals

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NCT05627960Recruiting

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

This is a first in human phase 1 study of AG01 an anti-Progranulin/Glycoprotein88 (PGRN/GP88) antibody in patients with advanced solid tumors. AG01 is a recombinant monoclonal antibody expressed in a ...

Baltimore, MDPHASE177 participantsA&G Pharmaceutical Inc.

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NCT06923527Recruiting

Circulating Tumor DNA

This is a single-arm, phase II study examining elacestrant in the adjuvant treatment of patients with ER+ breast cancer who test positive for circulating tumor DNA (ctDNA) during the screening period ...

Baltimore, MDPHASE250 participantsYale University

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NCT04234386Recruiting

GammaPod Dose Escalation Radiation for Early Stage Breast Cancer

The GammaPod machine was made by Xcision Medical Systems and is already FDA cleared to deliver focused radiation within the breast. Unlike current radiation machines, the GammaPod was designed specifi...

Baltimore, MDNA50 participantsUniversity of Maryland, Baltimore

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NCT06245889Recruiting

PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC

Eligible patients with stage 2 and 3 triple negative breast cancer will be treated with 4 cycles of neoadjuvant paclitaxel/carboplatin/pembrolizumab. A PET scan will be performed at baseline and after...

Baltimore, MDPHASE230 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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NCT06638294Recruiting

Study in Patients With Breast Cancer Leptomeningeal Metastasis

Traditional clinical trials in patients with breast cancer leptomeningeal disease (LMD) are challenging as patients often have a rapidly progressive course and prognosis is poor, making meeting standa...

Baltimore, MD30 participantsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

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NCT05029999Recruiting

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

This research study is being done to find out if the immunotherapy drugs called CDX-301 and CDX-1140 in combination with the standard chemotherapy treatment pegylated liposomal doxorubicin (PLD, Doxil...

Baltimore, MDPHASE130 participantsUniversity of Texas Southwestern Medical Center

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NCT02422641Recruiting

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

Management of leptomeningeal disease (LMD) in patients with metastatic breast cancer is an area of unmet clinical need. High-dose methotrexate (HD-MTX) is known to have activity against breast cancer ...

Baltimore, MDPHASE216 participantsWake Forest University Health Sciences

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About Breast Cancer Clinical Trials in Baltimore

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 16 breast cancer clinical trials recruiting participants in Baltimore, MD. These studies are seeking a combined 4,301 participants. Research is being sponsored by EXoPERT, UNC Lineberger Comprehensive Cancer Center, Sermonix Pharmaceuticals Inc. and 10 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Baltimore — FAQ

Are there breast cancer clinical trials in Baltimore?

Yes, there are 16 breast cancer clinical trials currently recruiting in Baltimore, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Baltimore?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Baltimore research site will contact you about next steps.

Are clinical trials in Baltimore free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Baltimore studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 16 active trials in Baltimore are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated September 1, 2026 from ClinicalTrials.gov