24 Substance Use Disorder Clinical Trials in Baltimore, MD (2026)

Q: How do I join a clinical trial in Baltimore?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Baltimore research site will contact you.

Recruiting Substance Use Disorder Studies in Baltimore

NCT06552741Recruiting

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ens...

Baltimore, MD10,000 participantsNational Institute on Drug Abuse (NIDA)

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NCT01036581Recruiting

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

Background: \- Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks. MRI...

Baltimore, MDNA1,000 participantsNational Institute on Drug Abuse (NIDA)

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NCT06513156Recruiting

Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

This is a two-group randomized controlled trial conducted at five hospitals across the U.S. designed to test the effectiveness of an Integrated infectious diseases/Substance Use Disorder outpatient cl...

Baltimore, MDNA304 participantsElana Rosenthal

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NCT07097545Recruiting

Change in Social Media Use and Well-being Among College Students Receiving a Two-week Exercise or Mindfulness Intervention

The investigators will be randomizing 300 college student participants with high levels of social media use into either a 1) control condition (no intervention), a 2) mindfulness meditation cognitive ...

Baltimore, MDNA300 participantsJohns Hopkins Bloomberg School of Public Health

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NCT06306443Recruiting

Buprenorphine for Individuals in Jail

This study is an open label randomized controlled trial of extended-release buprenorphine (BRIXADI, XR-B) vs. sublingual buprenorphine (SL-B) in a large metropolitan jail. An open-label design will ra...

Baltimore, MDPHASE3240 participantsFriends Research Institute, Inc.

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NCT06548490Recruiting

GLP-1R Agonist Treatment for Opioid Use Disorder

The goal of this clinical trial is to learn if semaglutide can reduce illicit opioid use in adults in outpatient treatment for opioid use disorder, and who are receiving either buprenorphine or methad...

Baltimore, MDPHASE2200 participantsMilton S. Hershey Medical Center

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NCT03845205Recruiting

Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions ...

Baltimore, MDNA200 participantsJohns Hopkins University

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NCT05973838Recruiting

Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce po...

Baltimore, MDNA160 participantsUniversity of Maryland, College Park

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NCT05459402Recruiting

Divided or Single Exposure (DOSE) Study

This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder....

Baltimore, MDPHASE2150 participantsUniversity of Maryland, Baltimore

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NCT06954402Recruiting

Resilience Among Individuals With Opioid Use Disorder

The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive,...

Baltimore, MDNA125 participantsJohns Hopkins University

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NCT05732207Recruiting

Cerebellar Involvement in Alcohol Use Disorder (AUD)

The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questi...

Baltimore, MDNA122 participantsJohns Hopkins University

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NCT05511909Recruiting

Evaluating Buspirone to Treat Opioid Withdrawal

The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving amo...

Baltimore, MDPHASE2100 participantsUniversity of Maryland, Baltimore

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NCT06067737Recruiting

Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder

This study will examine the effect of a single high dose of psilocybin therapy (30 mg) versus a very low dose (1 mg) as an adjunctive therapy to individuals undergoing standard-of-care outpatient bupr...

Baltimore, MDPHASE290 participantsJohns Hopkins University

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NCT05913752Recruiting

A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects

The primary objective of this study is to find the tolerable dose and characterize the safety and pharmacokinetics/ pharmacodynamics (PK/PD) of single and repeated dose of CMND-100 in Healthy Voluntee...

Baltimore, MDPHASE184 participantsClearmind Medicine Inc.

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NCT06774248Recruiting

Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD). The m...

Baltimore, MDNA80 participantsPotomac Health Foundations

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NCT06015893Recruiting

Semaglutide Therapy for Alcohol Reduction (STAR)

Background: Alcohol use disorder (AUD) is a problematic pattern of alcohol use accompanied by clinically significant medical consequences. Medications can help most people reduce their drinking, but ...

Baltimore, MDPHASE280 participantsNational Institute on Drug Abuse (NIDA)

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NCT05829655Recruiting

Measuring Acute Drug Demand in Humans

This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs....

Baltimore, MDEARLY_PHASE175 participantsUniversity of Maryland, Baltimore

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NCT06943859Recruiting

Ketamine for Opioid Use Disorder

The goal of this clinical trial is to learn if ketamine works to reduce craving for opioids in adults entering methadone treatment for opioid use disorder. The main questions it aims to answer are: *...

Baltimore, MDPHASE250 participantsUniversity of Maryland, Baltimore

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NCT06860607Recruiting

Environment and Alcohol: A Pilot Study

Background: Alcohol use disorder (AUD) is a chronic disease that causes more than 140,000 US deaths each year. AUD treatment often includes therapy and medication. Some people with AUD may also benef...

Baltimore, MDPHASE144 participantsNational Institute on Drug Abuse (NIDA)

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NCT07104123Recruiting

Substance Use in Pregnant People - Optimizing Retention in Treatment

Substance use during pregnancy is a leading cause of maternal morbidity and mortality in the United States, with 55-80% of postpartum patients disengaging from substance use disorder (SUD) treatment w...

Baltimore, MDNA40 participantsWashington University School of Medicine

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NCT06696157Recruiting

EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residences on MOUD"

The United States is experiencing an unprecedented opioid epidemic. Medications for opioid use disorder (MOUD), such as methadone, buprenorphine, and extended-release naltrexone, are the recommended s...

Baltimore, MDNA35 participantsPotomac Health Foundations

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NCT07153029Recruiting

Older Adults, Methadone, and Cognitive Function

The increasing prevalence of opioid use disorder (OUD) among older adults, coupled with high overdose rates and cognitive impairments associated with opioid use, highlights a critical gap in addiction...

Baltimore, MDNA30 participantsUniversity of Maryland, Baltimore

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NCT06089707Recruiting

Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fentanyl

The opioid overdose epidemic has persisted for several decades and is now further complicated by the permeation of fentanyl into the illicit opioid supply. While the effectiveness of medications to tr...

Baltimore, MDPHASE325 participantsJohns Hopkins University

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NCT05807139Recruiting

Spironolactone in Alcohol Use Disorder (SAUD)

Background: Alcohol use disorder (AUD) affects about 29.5 million people in the United States. Only 3 medicines have been approved by Food and Drug Administration to treat AUD. Researchers want to fi...

Baltimore, MDPHASE120 participantsNational Institute on Drug Abuse (NIDA)

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About Substance Use Disorder Clinical Trials in Baltimore

Substance use disorder is a condition where the use of substances leads to health issues, disability, and failure to meet responsibilities. It encompasses alcohol, opioid, stimulant, and other drug addictions. Treatment includes behavioral therapy, medication-assisted treatment, and support programs.

There are currently 24 substance use disorder clinical trials recruiting participants in Baltimore, MD. These studies are seeking a combined 13,554 participants. Research is being sponsored by National Institute on Drug Abuse (NIDA), Elana Rosenthal, Johns Hopkins Bloomberg School of Public Health and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Substance Use Disorder Clinical Trials in Baltimore — FAQ

Are there substance use disorder clinical trials in Baltimore?

Yes, there are 24 substance use disorder clinical trials currently recruiting in Baltimore, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Baltimore?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Baltimore research site will contact you about next steps.

Are clinical trials in Baltimore free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Baltimore studies also compensate for your time and travel.

What substance use disorder treatments are being tested?

The 24 active trials in Baltimore are testing new therapies including novel drugs, biologics, and treatment approaches for substance use disorder.

Data updated July 18, 2026 from ClinicalTrials.gov