Bethesda, MD5 Active Studies

Depression Clinical Trials in Bethesda, MD

Find 5 actively recruiting depression clinical trials in Bethesda, MD. Connect with local research sites and explore new treatment options.

5
Active Trials
1
Sponsors
5,342
Enrolling

Recruiting Depression Studies in Bethesda

NCT03388606Recruiting

Characterization and Treatment of Adolescent Depression

This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when...

Bethesda, MD4,100 participantsNational Institute of Mental Health (NIMH)
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NCT04877977Recruiting

Long-term Observation of Participants With Mood Disorders

Background: More than 12,000 people have taken part in research at the Experimental Therapeutics \& Pathophysiology Branch at the National Institute of Mental Health Intramural Program. This has led ...

Bethesda, MD1,000 participantsNational Institute of Mental Health (NIMH)
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NCT05703685Recruiting

[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs). Research...

Bethesda, MDPHASE1108 participantsNational Institute of Mental Health (NIMH)
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NCT03973268Recruiting

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work. A ...

Bethesda, MDPHASE170 participantsNational Institute of Mental Health (NIMH)
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NCT04582916Recruiting

PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

Background: Researchers developed \[11C\]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation. Researchers want to see the levels of COX-1 (mea...

Bethesda, MDPHASE164 participantsNational Institute of Mental Health (NIMH)
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About Depression Clinical Trials in Bethesda

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 5 depression clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 5,342 participants. Research is being sponsored by National Institute of Mental Health (NIMH). Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Bethesda — FAQ

Are there depression clinical trials in Bethesda?

Yes, there are 5 depression clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What depression treatments are being tested?

The 5 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 17, 2026 from ClinicalTrials.gov