11 Epilepsy Clinical Trials in Bethesda, MD (2026)

Q: How do I join a clinical trial in Bethesda?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you.

Recruiting Epilepsy Studies in Bethesda

NCT03478852Recruiting

Investigating Epilepsy: Screening and Evaluation

Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not. Researchers want people who have diagnosed or suspected epile...

Bethesda, MD1,000 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

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NCT02107989Recruiting

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization o...

Bethesda, MD700 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

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NCT05716100Recruiting

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

The X-TOLE3 Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and tolerability of XEN1101 administered as adjunctive thera...

Bethesda, MDPHASE3360 participantsXenon Pharmaceuticals Inc.

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NCT07563881Recruiting

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in r...

Bethesda, MDPHASE3333 participantsRapport Therapeutics Inc.

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NCT01273129Recruiting

Surgery as a Treatment for Medically Intractable Epilepsy

Background: \- Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical ...

Bethesda, MD300 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

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NCT06999902Recruiting

Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)

A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults With Focal Seizures (POWER1)...

Bethesda, MDPHASE2230 participantsPraxis Precision Medicines

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NCT07233239Recruiting

A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures

Cannabidiol oral solution (CBD-OS) is approved in the US for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or Tuberous sclerosis complex (TSC) in patie...

Bethesda, MDPHASE1100 participantsJazz Pharmaceuticals

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NCT02639325Recruiting

Tumor Related Epilepsy

Background: Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possibl...

Bethesda, MD100 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

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NCT06908356Recruiting

An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures

An Open Label Clinical Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adult Patients With Focal Onset or Primary Generalized Tonic-Clonic Seizures...

Bethesda, MDPHASE250 participantsPraxis Precision Medicines

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NCT02531880Recruiting

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Background: \- The blood-brain barrier separates the brain from the rest of the body. Epilepsy is a neurological disease that causes seizures. It can affect this barrier. Researchers think a contrast...

Bethesda, MDPHASE140 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

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NCT06063850Recruiting

AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

The main goals of this clinical study are to learn if AMT-260 is safe and tolerable and works to reduce the frequency of seizures in adults with unilateral mesial temporal lobe epilepsy (MTLE)....

Bethesda, MDPHASE112 participantsUniQure Biopharma B.V.

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About Epilepsy Clinical Trials in Bethesda

Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures caused by abnormal electrical activity in the brain. It affects about 50 million people worldwide. Treatment includes antiseizure medications, surgery, and neurostimulation devices.

There are currently 11 epilepsy clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 3,225 participants. Research is being sponsored by National Institute of Neurological Disorders and Stroke (NINDS), Xenon Pharmaceuticals Inc., Rapport Therapeutics Inc. and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Epilepsy Clinical Trials in Bethesda — FAQ

Are there epilepsy clinical trials in Bethesda?

Yes, there are 11 epilepsy clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What epilepsy treatments are being tested?

The 11 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for epilepsy.

Data updated July 17, 2026 from ClinicalTrials.gov