21 Multiple Sclerosis Clinical Trials in Bethesda, MD (2026)

Q: How do I join a clinical trial in Bethesda?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you.

Recruiting Multiple Sclerosis Studies in Bethesda

NCT00026884Recruiting

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

Selected individuals suspected of having or with prior biopsy proof of malignant disease will be seen in the Urologic Oncology Branch, NCI. Blood samples may be collected at the time of the initial vi...

Bethesda, MD5,950 participantsNational Cancer Institute (NCI)

View Study Details

NCT01353547Recruiting

Genes and Environment in Multiple Sclerosis

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease cause...

Bethesda, MD5,000 participantsColumbia University

View Study Details

NCT00900198Recruiting

Collection of Tissue Samples for Cancer Research

Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection ...

Bethesda, MD5,000 participantsNational Cancer Institute (NCI)

View Study Details

NCT00001248Recruiting

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures. In addition to studying the natural history of untreated ...

Bethesda, MD3,750 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

View Study Details

NCT03269578Recruiting

Sample Collection and Tracking for the Developmental Therapeutics Clinic

Background: People who join a study in the Developmental Therapeutics Clinic (DTC) have tests. These include blood draws and biopsies. Researchers collect data from these samples. Some people take pa...

Bethesda, MD3,000 participantsNational Cancer Institute (NCI)

View Study Details

NCT01915225Recruiting

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

Background: \- Recent advances in cancer research have led to new therapies to treat the disease. It is important to continue these advances and discover new ones. To do that, researchers need tissue...

Bethesda, MD1,800 participantsNational Cancer Institute (NCI)

View Study Details

NCT05170126Recruiting

A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring

The purpose of this study is to provide information on maternal, fetal, and infant outcomes following exposure of ozanimod during pregnancy so that participants and physicians can weigh the benefits a...

Bethesda, MD1,182 participantsBristol-Myers Squibb

View Study Details

NCT00033137Recruiting

Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

This study will investigate the genetic cause of Birt Hogg-Dube (BHD) syndrome and the relationship of this disorder to kidney cancer. BHD is a rare inherited condition characterized by papules, or bu...

Bethesda, MD950 participantsNational Cancer Institute (NCI)

View Study Details

NCT06462196Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different ...

Bethesda, MD500 participantsNational Institute of Mental Health (NIMH)

View Study Details

NCT03805919Recruiting

Men at High Genetic Risk for Prostate Cancer

Background: Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific ...

Bethesda, MD500 participantsNational Cancer Institute (NCI)

View Study Details

NCT05327023Recruiting

Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high. Researchers want to see if giving the transplant rec...

Bethesda, MDPHASE1430 participantsNational Cancer Institute (NCI)

View Study Details

NCT01132885Recruiting

Defining the Brain Phenotype of Children With Williams Syndrome

Background: \- Little is known about how the brain changes during childhood and adolescence, how genes affect this process, or how the brains of people with 7q11.23 genetic variation change during th...

Bethesda, MD415 participantsNational Institute of Mental Health (NIMH)

View Study Details

NCT01834001Recruiting

Imaging Studies to Check the Local Response of Prostate Cancer to Radiation Therapy

Background: \- Radiation is a common treatment for prostate cancer. It helps damage tumor cells and causes them to die. Radiation can be effective, but some tumors may be harder to treat with radiati...

Bethesda, MD300 participantsNational Cancer Institute (NCI)

View Study Details

NCT03391778Recruiting

Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

This trial will evaluate long term safety of participants who have received AdaptImmune (ADP) adoptive cell therapy for up to 15 years following last adoptive cell therapy infusion....

Bethesda, MDPHASE1250 participantsUSWM CT, LLC

View Study Details

NCT02659956Recruiting

Pathological Basis of MRI Signal Changes in Multiple Sclerosis

Background: Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once i...

Bethesda, MD250 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

View Study Details

NCT03109288Recruiting

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Background: In people with multiple sclerosis (MS), brain and cerebrospinal fluid (CSF) biomarkers indicate inflammation or disease. Researchers want to see if 4 drugs given alone or combined affect ...

Bethesda, MDPHASE1250 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

View Study Details

NCT04541082Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this Phase 1, open-label, dose-escalation, and exploratory study is to evaluate the safety and tolerability profile (establish the maximum-tolerated dose) and evaluate the occ...

Bethesda, MDPHASE1102 participantsJazz Pharmaceuticals

View Study Details

NCT04449549Recruiting

Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

Background: People with rare cancers often have limited treatment options. The biology of rare cancers is not well understood. Researchers want to find better treatments for these cancers. They want ...

Bethesda, MDPHASE282 participantsNational Cancer Institute (NCI)

View Study Details

NCT03366116Recruiting

5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

Background: Blood, tissue, and tumor cells contain genes. Genes are made up of DNA. DNA is the "instruction book" for each cell. In some people with cancer, the genes that might have slowed the growt...

Bethesda, MDPHASE165 participantsNational Cancer Institute (NCI)

View Study Details

NCT05616650Recruiting

Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor

Background: The current standard treatment of prostate cancer is either surgery or radiation. Typically, this includes either the removal or radiation of the whole prostate gland. Many people now see...

Bethesda, MDPHASE242 participantsNational Cancer Institute (NCI)

View Study Details

NCT02784210Recruiting

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Background: Multiple sclerosis (MS) affects the brain, spinal cord, and optic nerves. MS lesions can appear on the MRI (magnetic resonance imaging) scans in many ways. Sometimes they light up from th...

Bethesda, MDPHASE230 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

View Study Details

About Multiple Sclerosis Clinical Trials in Bethesda

Multiple sclerosis (MS) is an autoimmune disease where the immune system attacks the protective covering of nerve fibers, causing communication problems between the brain and body. Symptoms vary widely and can include vision problems, fatigue, and mobility issues. Disease-modifying therapies have significantly improved outcomes.

There are currently 21 multiple sclerosis clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 29,848 participants. Research is being sponsored by National Cancer Institute (NCI), Columbia University, National Institute of Neurological Disorders and Stroke (NINDS) and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Multiple Sclerosis Clinical Trials in Bethesda — FAQ

Are there multiple sclerosis clinical trials in Bethesda?

Yes, there are 21 multiple sclerosis clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What multiple sclerosis treatments are being tested?

The 21 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for multiple sclerosis.

Data updated July 18, 2026 from ClinicalTrials.gov