8 Neurofibromatosis Clinical Trials in Bethesda, MD (2026)

Q: How do I join a clinical trial in Bethesda?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you.

Recruiting Neurofibromatosis Studies in Bethesda

NCT02544022Recruiting

Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

Background: People with neurofibromatosis 1 (NF1) who have plexiform neurofibromas (pNFs) can have pain that affects their daily lives. This study aims to improve questionnaires that measure their pa...

Bethesda, MD476 participantsNational Cancer Institute (NCI)

View Study Details

NCT00598351Recruiting

Natural History Study of Patients With Neurofibromatosis Type 2

Objective With this prospective natural experiment trial on neurofibromatosis type 2 (NF2) study, we hope to understand the factors leading to tumor progression and neurological disease burden in NF2...

Bethesda, MD269 participantsNational Institute of Neurological Disorders and Stroke (NINDS)

View Study Details

NCT06222203Recruiting

Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

Background: Neurofibromatosis type 1 (NF1) is a genetic disease that can cause many symptoms. About half of people with NF1 will develop benign (noncancerous) tumors along nerves in the skin, brain, ...

Bethesda, MD225 participantsNational Cancer Institute (NCI)

View Study Details

NCT06188741Recruiting

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

Plexiform neurofibromas (PN) are known to cause significant morbidity in children with NF1. The recent FDA approval for selumetinib in children 2 years and older with inoperable symptomatic PN was bas...

Bethesda, MDPHASE2200 participantsUniversity of Alabama at Birmingham

View Study Details

NCT06880991Recruiting

Development of Patient-Reported Outcome Measures Assessing Tumor Visibility and Appearance Concerns in Neurofibromatosis Type 1: A Qualitative Study

Background: Neurofibromatosis 1 (NF1) is a disease that causes tumors to grow along the nerves. These include plexiform neurofibromas (pNF) and cutaneous neurofibromas (cNF). Both pNF and cNF can be ...

Bethesda, MD110 participantsNational Cancer Institute (NCI)

View Study Details

NCT05361811Recruiting

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

Background: RASopathies are a group of genetic diseases that affect a child s development. They cause physical, cognitive, and behavioral symptoms. Caring for a child with a RASopathy can be stressfu...

Bethesda, MDNA70 participantsNational Cancer Institute (NCI)

View Study Details

NCT06507748Recruiting

A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)

Background: Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumors to grow along the nerves in the skin, brain, and other parts of the body. People with NF1 often have pain and may ...

Bethesda, MDNA70 participantsNational Cancer Institute (NCI)

View Study Details

NCT04750928Recruiting

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Background: NF1 is a genetic disease that causes tumors called atypical neurofibromas. These tumors, which arise from nerves, can cause serious medical problems. The only treatment is surgery. Resear...

Bethesda, MDPHASE155 participantsNational Cancer Institute (NCI)

View Study Details

About Neurofibromatosis Clinical Trials in Bethesda

Neurofibromatosis is a group of genetic conditions that cause tumors to grow on nerve tissue. NF1 is the most common type, causing skin changes and bone deformities. Treatment includes monitoring, surgery for problematic tumors, and MEK inhibitors for plexiform neurofibromas.

There are currently 8 neurofibromatosis clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 1,475 participants. Research is being sponsored by National Cancer Institute (NCI), National Institute of Neurological Disorders and Stroke (NINDS), University of Alabama at Birmingham. Clinical trial participation is free and participants receive study-related medical care at no cost.

Neurofibromatosis Clinical Trials in Bethesda — FAQ

Are there neurofibromatosis clinical trials in Bethesda?

Yes, there are 8 neurofibromatosis clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What neurofibromatosis treatments are being tested?

The 8 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for neurofibromatosis.

Data updated October 16, 2026 from ClinicalTrials.gov