Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Neurofibromatosis Clinical Trials
Neurofibromatosis clinical trials are recruiting across 17 cities. Here are the cities with the most active studies:
Neurofibromatosis Trial Phases
11 research organizations are sponsoring neurofibromatosis trials.
About Neurofibromatosis
Neurofibromatosis is a group of genetic conditions that cause tumors to grow on nerve tissue. NF1 is the most common type, causing skin changes and bone deformities. Treatment includes monitoring, surgery for problematic tumors, and MEK inhibitors for plexiform neurofibromas.
Clinical trials are advancing new treatments for neurofibromatosis. Currently, 19 studies are recruiting a combined 23,112 participants across the United States. Research is being conducted by 11 organizations including The Children's Tumor Foundation, David Miller, National Cancer Institute (NCI) and 8 others.
2026 Neurofibromatosis Research Landscape
As of July 2026, the neurofibromatosis clinical trial landscape includes 19 actively recruiting studies across 17 cities in the United States. These studies are collectively seeking 23,112 participants, with an average enrollment target of 1,216 per study.
The research spans multiple phases of development: 5 studies are in NA, 5 studies are in PHASE2, 5 studies are in PHASE1. Early-phase studies suggest new therapeutic approaches are being explored for neurofibromatosis.
Research is being led by 11 different organizations, including The Children's Tumor Foundation, David Miller, National Cancer Institute (NCI), Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS), and 6 others. The large number of sponsors reflects significant research interest and investment in neurofibromatosis treatment advancement.
Geographically, neurofibromatosis trials are most concentrated in Bethesda, Maryland (9 trials); Baltimore, Maryland (6 trials); Boston, Massachusetts (5 trials); Washington D.C., District of Columbia (4 trials); Los Angeles, California (4 trials) and 7 other cities.
Featured Neurofibromatosis Studies
Highlighted recruiting studies for neurofibromatosis, selected by enrollment size and research scope.
Neurofibromatosis (NF) Registry Portal
The NF Registry is a database of patient-reported symptoms, treatments, and experiences with their neurofibromatosis disease. It is a contact registry to relay clinical trial opportunities to targeted patient subgroups, and to supply de-identified disease data to researchers. It has the potential to become a natural history resource.
Neurofibromatosis Type 1 Tumor Early Detection Study
The goal of this observational study is to determine if a liquid biopsy (i.e. blood test) is an effective clinical tool for monitoring the development of malignant peripheral nerve sheath tumor (MPNST) among adults (18 years and older) with Neurofibromatosis Type 1 (NF1), compared to the current standard of care. The main questions it aims to answer are: How effective is liquid biopsy compared to...
Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)
Background: People with neurofibromatosis 1 (NF1) who have plexiform neurofibromas (pNFs) can have pain that affects their daily lives. This study aims to improve questionnaires that measure their pain, daily living, and physical functioning. Objectives: To examine and improve questionnaires about daily living for people with NF1 and pNFs. Eligibility: People ages 5 and older with NF1 and a p...
Frequently Asked Questions About Neurofibromatosis Clinical Trials
Are there neurofibromatosis clinical trials near me?
Yes, there are 19 neurofibromatosis clinical trials currently recruiting across 17+ cities in the United States, including Bethesda, Maryland; Baltimore, Maryland; Boston, Massachusetts. Browse the studies above to find one at a location convenient for you.
How do I join a neurofibromatosis clinical trial?
To join a neurofibromatosis clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are neurofibromatosis clinical trials free?
Yes, participation in neurofibromatosis clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of neurofibromatosis treatments are being studied?
Current neurofibromatosis clinical trials are testing a range of approaches across NA (5 studies), PHASE2 (5 studies), PHASE1 (5 studies). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 11 research organizations.
Is it safe to participate in neurofibromatosis clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 15, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 15, 2026 · Data from ClinicalTrials.gov