8 Major Depressive Disorder Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Major Depressive Disorder Studies in Birmingham

NCT06559306Recruiting

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant i...

Birmingham, ALPHASE3752 participantsJanssen Research & Development, LLC

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NCT04923685Recruiting

MicroRNA Correlates of Childhood Maltreatment and Suicidality

This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomar...

Birmingham, AL450 participantsUniversity of Alabama at Birmingham

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NCT06793397Recruiting

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD....

Birmingham, ALPHASE3330 participantsCybin IRL Limited

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NCT05437588Recruiting

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This...

Birmingham, ALNA240 participantsUniversity of Alabama at Birmingham

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NCT06633016Recruiting

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who ha...

Birmingham, ALPHASE2230 participantsAutobahn Therapeutics, Inc.

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NCT07553637Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD....

Birmingham, ALPHASE2178 participantsAlto Neuroscience

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NCT06547489Recruiting

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if GATE-251 works to treat depression in adults. It will also learn about the safety of GATE-251. The main questions it aims to answer are: Does GATE-251 r...

Birmingham, ALPHASE2164 participantsSyndeio Biosciences, Inc

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NCT07284667Recruiting

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatmen...

Birmingham, ALPHASE2153 participantsACADIA Pharmaceuticals Inc.

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About Major Depressive Disorder Clinical Trials in Birmingham

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 8 major depressive disorder clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 2,497 participants. Research is being sponsored by Janssen Research & Development, LLC, University of Alabama at Birmingham, Cybin IRL Limited and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in Birmingham — FAQ

Are there major depressive disorder clinical trials in Birmingham?

Yes, there are 8 major depressive disorder clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 8 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated October 18, 2026 from ClinicalTrials.gov