Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Major Depressive Disorder Clinical Trials
Major Depressive Disorder clinical trials are recruiting across 130 cities. Here are the cities with the most active studies:
Major Depressive Disorder Trial Phases
63 research organizations are sponsoring major depressive disorder trials.
About Major Depressive Disorder
Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.
Clinical trials are advancing new treatments for major depressive disorder. Currently, 100 studies are recruiting a combined 39,753 participants across the United States. Research is being conducted by 63 organizations including Adams Clinical, Eli Lilly and Company, Neurocrine Biosciences and 60 others.
2026 Major Depressive Disorder Research Landscape
As of July 2026, the major depressive disorder clinical trial landscape includes 100 actively recruiting studies across 130 cities in the United States. These studies are collectively seeking 39,753 participants, with an average enrollment target of 398 per study.
The research spans multiple phases of development: 41 studies are in NA, 22 studies are in PHASE2, 19 studies are in PHASE3, 6 studies are in PHASE4, 6 studies are in PHASE1, 1 study is in EARLY_PHASE1. The presence of Phase 3 trials indicates that some major depressive disorder treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 63 different organizations, including Adams Clinical, Eli Lilly and Company, Neurocrine Biosciences, Janssen Research & Development, LLC, National Institute on Drug Abuse (NIDA), and 58 others. The large number of sponsors reflects significant research interest and investment in major depressive disorder treatment advancement.
Geographically, major depressive disorder trials are most concentrated in Los Angeles, California (12 trials); Boston, Massachusetts (11 trials); New York, New York (10 trials); Miami, Florida (10 trials); Little Rock, Arkansas (9 trials) and 7 other cities.
Featured Major Depressive Disorder Studies
Highlighted recruiting studies for major depressive disorder, selected by enrollment size and research scope.
Triage Survey for Psychiatry Research Eligibility
TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials.
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms. The trial is divided into three periods as follows: a screening period that will last approximately 1 month, a treatment period that will last a minimum of 12 months, and the follow up period that will last appr...
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD.
Frequently Asked Questions About Major Depressive Disorder Clinical Trials
Are there major depressive disorder clinical trials near me?
Yes, there are 100 major depressive disorder clinical trials currently recruiting across 130+ cities in the United States, including Los Angeles, California; Boston, Massachusetts; New York, New York. Browse the studies above to find one at a location convenient for you.
How do I join a major depressive disorder clinical trial?
To join a major depressive disorder clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are major depressive disorder clinical trials free?
Yes, participation in major depressive disorder clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of major depressive disorder treatments are being studied?
Current major depressive disorder clinical trials are testing a range of approaches across NA (41 studies), PHASE2 (22 studies), PHASE3 (19 studies), PHASE4 (6 studies), PHASE1 (6 studies), EARLY_PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 63 research organizations.
Is it safe to participate in major depressive disorder clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 17, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 17, 2026 · Data from ClinicalTrials.gov