Recruiting Major Depressive Disorder Studies in Orange
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD....
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)...
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants ...
Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
This is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive ...
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....
Study to Evaluate Efficacy and Safety of Ropanicant in MDD Patients
The primary objective is to evaluate the efficacy of Ropanicant at two different dosage levels compared to placebo in patients with Major Depressive Disorder (MDD)....
About Major Depressive Disorder Clinical Trials in Orange
Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.
There are currently 6 major depressive disorder clinical trials recruiting participants in Orange, CALIFORNIA. These studies are seeking a combined 2,345 participants. Research is being sponsored by Neurocrine Biosciences, COMPASS Pathways, Xenon Pharmaceuticals Inc. and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.
Major Depressive Disorder Clinical Trials in Orange — FAQ
Are there major depressive disorder clinical trials in Orange?
Yes, there are 6 major depressive disorder clinical trials currently recruiting in Orange, CALIFORNIA. Browse the studies on this page to find one that fits.
How do I join a clinical trial in Orange?
Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Orange research site will contact you about next steps.
Are clinical trials in Orange free?
Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Orange studies also compensate for your time and travel.
What major depressive disorder treatments are being tested?
The 6 active trials in Orange are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.
Data updated March 2, 2026 from ClinicalTrials.gov