Phoenix, ARIZONA5 Active Studies

Major Depressive Disorder Clinical Trials in Phoenix, ARIZONA

Find 5 actively recruiting major depressive disorder clinical trials in Phoenix, ARIZONA. Connect with local research sites and explore new treatment options.

5
Active Trials
5
Sponsors
2,221
Enrolling

Recruiting Major Depressive Disorder Studies in Phoenix

RecruitingPhoenix, ARIZONANCT06029439

Study to Assess the Safety and Effectiveness of NMRA-335140-501

This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who ...

1,000 participants
Neumora Therapeutics, Inc.
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RecruitingPhoenix, ARIZONANCT06775379

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants ...

450 participants
Xenon Pharmaceuticals Inc.
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RecruitingPhoenix, ARIZONANCT05922878

Study of ALTO-300 in MDD

The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics....

321 participants
Alto Neuroscience
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RecruitingPhoenix, ARIZONANCT06633016

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who ha...

230 participants
Autobahn Therapeutics, Inc.
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RecruitingPhoenix, ARIZONANCT06564818

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD....

220 participants
Cybin IRL Limited
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About Major Depressive Disorder Clinical Trials in Phoenix

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 5 major depressive disorder clinical trials recruiting participants in Phoenix, ARIZONA. These studies are seeking a combined 2,221 participants. Research is being sponsored by Neumora Therapeutics, Inc., Xenon Pharmaceuticals Inc., Alto Neuroscience and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in Phoenix — FAQ

Are there major depressive disorder clinical trials in Phoenix?

Yes, there are 5 major depressive disorder clinical trials currently recruiting in Phoenix, ARIZONA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Phoenix?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Phoenix research site will contact you about next steps.

Are clinical trials in Phoenix free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Phoenix studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 5 active trials in Phoenix are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated March 2, 2026 from ClinicalTrials.gov