27 Parkinsons Disease Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Parkinsons Disease Studies in Birmingham

NCT04994015Recruiting

Parkinson's Foundation PD GENEration Genetic Registry

Development of a central repository for PD-related genomic data for future research....

Birmingham, AL25,000 participantsParkinson's Foundation

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NCT04477785Recruiting

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biolo...

Birmingham, AL4,500 participantsMichael J. Fox Foundation for Parkinson's Research

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NCT06719583Recruiting

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The stud...

Birmingham, AL2,000 participantsMichael J. Fox Foundation for Parkinson's Research

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NCT05878769Recruiting

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

The purpose of this study is to assess the long-term safety and to explore the efficacy of astegolimab in participants with chronic obstructive pulmonary disease (COPD) who have completed the 52-week ...

Birmingham, ALPHASE32,000 participantsHoffmann-La Roche

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NCT05033990Recruiting

SPIROMICS Study of Early COPD Progression (SOURCE)

This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals. The study has three main goals:...

Birmingham, AL1,000 participantsUniversity of Massachusetts, Worcester

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NCT07082738Recruiting

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

This Phase IIb dose-ranging study will evaluate the efficacy and safety of 3 different doses of AZD6793 compared with placebo tablets in participants with moderate to very severe chronic obstructive p...

Birmingham, ALPHASE2987 participantsAstraZeneca

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NCT07174310Recruiting

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable sympt...

Birmingham, ALPHASE3900 participantsHoffmann-La Roche

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NCT07417111Recruiting

Continued Pressure for Alveolar Protection (CPAP Trial)

The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopu...

Birmingham, ALNA860 participantsNICHD Neonatal Research Network

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NCT06376994Recruiting

Multi-Center Clean Air Randomized Controlled Trial in COPD

This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk...

Birmingham, ALPHASE3770 participantsJHSPH Center for Clinical Trials

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NCT05204888Recruiting

myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home

Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs. usual COPD medical care, for at least 1 year a...

Birmingham, ALNA642 participantsTemple University

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NCT06976268Recruiting

A Study to Determine if BHV-8000 is Effective, Safe and Tolerable as a Treatment for Adults Living With Early Parkinson's Disease

A study to determine if BHV-8000 is efficacious, safe and tolerable in adults diagnosed with early Parkinson's disease....

Birmingham, ALPHASE2550 participantsBiohaven Therapeutics Ltd.

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NCT07284784Recruiting

A Study of Buntanetap in Participants With PD

This study will examine the long-term safety of buntanetap in participants with PD. This will be a 36-month open-label safety study. This study will be conducted with two cohorts. Cohort 1 will enroll...

Birmingham, ALPHASE2500 participantsAnnovis Bio Inc.

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NCT07059091Recruiting

Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD

This research is being done to test if a drug called omalizumab can help people with Chronic Obstructive Pulmonary Disease (COPD) and allergies. Each participant will be in the study for about 16 mon...

Birmingham, ALPHASE2334 participantsJohns Hopkins University

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NCT06891755Recruiting

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphys...

Birmingham, ALNA250 participantsApreo Health, Inc.

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NCT03457493Recruiting

The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy

The primary objective of this substudy is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET ligand \[18F\]DPA-714 in participants ...

Birmingham, ALPHASE1205 participantsUniversity of Alabama at Birmingham

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NCT07051707Recruiting

Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

The dNerva Lung Denervation System is one-time treatment intended to improve breathing in Chronic Obstructive Pulmonary Disease (COPD) patients on standard medical care. The purpose of this study is t...

Birmingham, ALNA200 participantsNuvaira, Inc.

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NCT06496620Recruiting

A Study to Evaluate Solrikitug in Participants With COPD (ZION)

A Randomized, Double-blind, Placebo-controlled, Multiple Dose-Ranging Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Solrikitug in Participants with Chronic Obstru...

Birmingham, ALPHASE2171 participantsUniquity One (UNI)

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NCT06855433Recruiting

Colchicine to Reduce Your SympToms And Lower Levels of Inflammation, Zeroing in on Effective CPPD Disease Treatment

The goal of this clinical trial is to learn if colchicine reduces levels of proteins indicating inflammation in the blood in individuals with calcium pyrophosphate deposition (CPPD) disease. The trial...

Birmingham, ALPHASE2150 participantsBrigham and Women's Hospital

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NCT04735458Recruiting

Investigating Inhibitory Control Networks in Parkinson's Disease

The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders co...

Birmingham, ALNA140 participantsUniversity of Alabama at Birmingham

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NCT04061135Recruiting

Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These moveme...

Birmingham, ALNA90 participantsUniversity of Alabama at Birmingham

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NCT07222410Recruiting

Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital

The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with h...

Birmingham, ALNA70 participantsFisher and Paykel Healthcare

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NCT06289582Recruiting

Longitudinal TSPO PET Imaging With [18F]DPA-714 in PPMI (PPMI DPA-714 PET Imaging)

The overall goal of this protocol is to investigate \[18F\]DPA-714 binding in prodromal and early manifest Parkinson's Disease (PD) and to determine the baseline and change from baseline in \[18F\]DPA...

Birmingham, ALEARLY_PHASE160 participantsUniversity of Alabama at Birmingham

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NCT05270525Recruiting

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

This is a randomized, double-blind, placebo-controlled, two-period cross-over study of nebulized ensifentrine (3 mg) or placebo administered BID for two 8-week Treatment Periods. All participants with...

Birmingham, ALPHASE256 participantsVerona Pharma plc

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NCT06182072Recruiting

ProAgio in Pancreatic Ductal Adenocarcinoma (PDAC)

This is an open-label Phase I/Ib dose-escalation, dose-expansion clinical trial of the safety, pharmacokinetics and clinical activity of ProAgio combined with gemcitabine, nab-paclitaxel (G-nP) or gem...

Birmingham, ALPHASE146 participantsProDa BioTech, LLC

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NCT06169852Recruiting

Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD

Our goal is to better understand how DBS modifies local neuronal activity and to pioneer device technologies that can record local DBS-evoked potentials (DLEPs) to guide therapy. Our vision is for a p...

Birmingham, ALNA36 participantsUniversity of Alabama at Birmingham

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NCT05482126Recruiting

Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease

The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available....

Birmingham, AL30 participantsUniversity of Alabama at Birmingham

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NCT07557706Recruiting

Using taVNS to Modulate Cardiovascular Function in Individuals With Neurologic Disease

The purpose of this study is to find out whether a type of gentle nerve stimulation, called transcutaneous auricular Vagus Nerve Stimulation (taVNS), can help improve how the body regulates heart rate...

Birmingham, ALPHASE124 participantsUniversity of Alabama at Birmingham

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About Parkinsons Disease Clinical Trials in Birmingham

Parkinson's disease is a progressive nervous system disorder that affects movement, causing tremors, stiffness, and difficulty with balance. It results from the loss of dopamine-producing neurons in the brain. Treatment includes medications, deep brain stimulation, and emerging therapies targeting disease modification.

There are currently 27 parkinsons disease clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 41,571 participants. Research is being sponsored by Parkinson's Foundation, Michael J. Fox Foundation for Parkinson's Research, Hoffmann-La Roche and 16 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Parkinsons Disease Clinical Trials in Birmingham — FAQ

Are there parkinsons disease clinical trials in Birmingham?

Yes, there are 27 parkinsons disease clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What parkinsons disease treatments are being tested?

The 27 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for parkinsons disease.

Data updated July 17, 2026 from ClinicalTrials.gov