13 Sickle Cell Disease Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Sickle Cell Disease Studies in Birmingham

NCT06385886Recruiting

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

The goal of this observational study is to help us understand more about the best ways to help individuals living with Sickle Cell Disease (SCD) get the best care. The main question it aims to answer ...

Birmingham, AL500 participantsRTI International

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NCT06609226Recruiting

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect ha...

Birmingham, ALPHASE3480 participantsNovo Nordisk A/S

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NCT06941389Recruiting

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

The WeDecide study is a large observational study comparing the long-term effects of matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therap...

Birmingham, AL480 participantsUniversity of Rochester

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NCT06612268Recruiting

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

This study is conducted to confirm whether etavopivat works well at reducing the number of Vaso-occlusive crisis VOCs (sickle cell pain crises) caused by obstructions in blood vessels in adults and ad...

Birmingham, ALPHASE3408 participantsNovo Nordisk A/S

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NCT06439082Recruiting

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without hydroxyurea/hydroxycarbamide ther...

Birmingham, ALPHASE3354 participantsNovartis Pharmaceuticals

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NCT06481306Recruiting

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, pH and food effect, and preliminary efficacy of BMS-986470 in healthy volunteers and partic...

Birmingham, ALPHASE1224 participantsBristol-Myers Squibb

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NCT06975865Recruiting

The Efficacy and Safety of Rilzabrutinib in Patients Aged 10 to 65 Years With Sickle-cell Disease

This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, group-sequential study (Part A), followed by an open-label LTE period (Part B) to investigate the efficacy, and saf...

Birmingham, ALPHASE3192 participantsSanofi

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NCT06546670Recruiting

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary food effect of ITU512 as well as the fetal hemoglobin (HbF)-inducing capacity of ITU512. This ...

Birmingham, ALPHASE1161 participantsNovartis Pharmaceuticals

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NCT04657822Recruiting

Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study

This is a multi-center multi-national rollover study to allow continued access to crizanlizumab for patients with sickle cell disease (SCD) who are on crizanlizumab treatment in a Novartis-sponsored s...

Birmingham, ALPHASE4130 participantsNovartis Pharmaceuticals

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NCT05336201Recruiting

Cognitive Remediation Intervention to Prepare for Transition of Care

Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents...

Birmingham, ALPHASE2120 participantsUniversity of Alabama at Birmingham

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NCT07187973Recruiting

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

This is an open-label, multicenter, within-participant dose-escalation study examining up to 3 dose levels of DISC-3405 and will assess the safety, tolerability, PK, and PD of DISC 3405 in participant...

Birmingham, ALPHASE124 participantsDisc Medicine, Inc

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NCT05377372Recruiting

Early Life Exposures Among Children With Sickle Cell Disease

This study is being conducted to determine the relationship between early childhood exposures, such as Adverse Childhood Experiences, Social Determinants of Health and nutrition/breastfeeding, among c...

Birmingham, ALNA20 participantsUniversity of Alabama at Birmingham

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NCT06442761Recruiting

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

This study is being done to see if the study drug, motixafortide, is safe in participants with sickle cell disease (SCD). Investigators also want to see if the drug will help the body increase the num...

Birmingham, ALPHASE115 participantsSt. Jude Children's Research Hospital

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About Sickle Cell Disease Clinical Trials in Birmingham

Sickle cell disease is a group of inherited blood disorders where abnormal hemoglobin causes red blood cells to become rigid and sickle-shaped. It causes pain crises, organ damage, and shortened life expectancy. Treatment includes hydroxyurea, blood transfusions, and gene therapy.

There are currently 13 sickle cell disease clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 3,108 participants. Research is being sponsored by RTI International, Novo Nordisk A/S, University of Rochester and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sickle Cell Disease Clinical Trials in Birmingham — FAQ

Are there sickle cell disease clinical trials in Birmingham?

Yes, there are 13 sickle cell disease clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What sickle cell disease treatments are being tested?

The 13 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for sickle cell disease.

Data updated August 28, 2026 from ClinicalTrials.gov