Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Sickle Cell Disease Clinical Trials
Sickle Cell Disease clinical trials are recruiting across 82 cities. Here are the cities with the most active studies:
Sickle Cell Disease Trial Phases
60 research organizations are sponsoring sickle cell disease trials.
About Sickle Cell Disease
Sickle cell disease is a group of inherited blood disorders where abnormal hemoglobin causes red blood cells to become rigid and sickle-shaped. It causes pain crises, organ damage, and shortened life expectancy. Treatment includes hydroxyurea, blood transfusions, and gene therapy.
Clinical trials are advancing new treatments for sickle cell disease. Currently, 100 studies are recruiting a combined 60,645 participants across the United States. Research is being conducted by 60 organizations including Cyprus Institute of Neurology and Genetics, St. Jude Children's Research Hospital, Medical College of Wisconsin and 57 others.
2026 Sickle Cell Disease Research Landscape
As of July 2026, the sickle cell disease clinical trial landscape includes 100 actively recruiting studies across 82 cities in the United States. These studies are collectively seeking 60,645 participants, with an average enrollment target of 606 per study.
The research spans multiple phases of development: 29 studies are in NA, 28 studies are in PHASE2, 22 studies are in PHASE1, 7 studies are in PHASE3, 4 studies are in PHASE4, 1 study is in EARLY_PHASE1. The presence of Phase 3 trials indicates that some sickle cell disease treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 60 different organizations, including Cyprus Institute of Neurology and Genetics, St. Jude Children's Research Hospital, Medical College of Wisconsin, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center, and 55 others. The large number of sponsors reflects significant research interest and investment in sickle cell disease treatment advancement.
Geographically, sickle cell disease trials are most concentrated in Bethesda, Maryland (14 trials); Chicago, Illinois (14 trials); Memphis, Tennessee (13 trials); Atlanta, Georgia (13 trials); Birmingham, Alabama (13 trials) and 7 other cities.
Featured Sickle Cell Disease Studies
Highlighted recruiting studies for sickle cell disease, selected by enrollment size and research scope.
Study of the Role of Genetic Modifiers in Hemoglobinopathies
This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).
Sickle Cell Clinical Research and Intervention Program
Despite the important work of previous sickle cell disease (SCD) cohort studies, there remain many understudied areas that require investigation. An important knowledge deficit is the slow but progressive process of chronic end-organ dysfunction. The majority of organ dysfunction becomes apparent in the young adult years, but comprehensive assessment of adults and understanding of predictors of ad...
Sickle Cell Improvement: Enhancing Care in the Emergency Department
Sickle cell disease (SCD) is an inherited blood disorder affecting approximately 36,000 children in the United States, approximately 90% of whom are Black. The disease is characterized by recurrent, severe pain crises which result in high rates of emergency department visits and hospitalizations, and decreased quality of life. The National Heart, Lung and Blood Institute, as well as the American S...
Frequently Asked Questions About Sickle Cell Disease Clinical Trials
Are there sickle cell disease clinical trials near me?
Yes, there are 100 sickle cell disease clinical trials currently recruiting across 82+ cities in the United States, including Bethesda, Maryland; Chicago, Illinois; Memphis, Tennessee. Browse the studies above to find one at a location convenient for you.
How do I join a sickle cell disease clinical trial?
To join a sickle cell disease clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are sickle cell disease clinical trials free?
Yes, participation in sickle cell disease clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of sickle cell disease treatments are being studied?
Current sickle cell disease clinical trials are testing a range of approaches across NA (29 studies), PHASE2 (28 studies), PHASE1 (22 studies), PHASE3 (7 studies), PHASE4 (4 studies), EARLY_PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 60 research organizations.
Is it safe to participate in sickle cell disease clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov