Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Myelofibrosis Clinical Trials
Myelofibrosis clinical trials are recruiting across 58 cities. Here are the cities with the most active studies:
Myelofibrosis Trial Phases
26 research organizations are sponsoring myelofibrosis trials.
About Myelofibrosis
Myelofibrosis is a serious bone marrow disorder that disrupts normal blood cell production, leading to extensive scarring in the bone marrow. It can cause severe anemia, weakness, and an enlarged spleen. Treatment includes JAK inhibitors, blood transfusions, and stem cell transplant.
Clinical trials are advancing new treatments for myelofibrosis. Currently, 30 studies are recruiting a combined 3,106 participants across the United States. Research is being conducted by 26 organizations including Center for International Blood and Marrow Transplant Research, Kartos Therapeutics, Inc., Novartis Pharmaceuticals and 23 others.
2026 Myelofibrosis Research Landscape
As of July 2026, the myelofibrosis clinical trial landscape includes 30 actively recruiting studies across 58 cities in the United States. These studies are collectively seeking 3,106 participants, with an average enrollment target of 104 per study.
The research spans multiple phases of development: 19 studies are in PHASE1, 13 studies are in PHASE2, 2 studies are in PHASE3, 1 study is in EARLY_PHASE1. The presence of Phase 3 trials indicates that some myelofibrosis treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 26 different organizations, including Center for International Blood and Marrow Transplant Research, Kartos Therapeutics, Inc., Novartis Pharmaceuticals, Sumitomo Pharma America, Inc., University of Michigan Rogel Cancer Center, and 21 others. The large number of sponsors reflects significant research interest and investment in myelofibrosis treatment advancement.
Geographically, myelofibrosis trials are most concentrated in New York, New York (9 trials); Houston, Texas (8 trials); Duarte, California (5 trials); Ann Arbor, Michigan (4 trials); Tampa, Florida (4 trials) and 7 other cities.
Featured Myelofibrosis Studies
Highlighted recruiting studies for myelofibrosis, selected by enrollment size and research scope.
Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis
This observational study will compare outcomes of a prospectively-enrolled cohort of Hematopoietic Stem Cell Transplant (HCT) recipients with outcomes of a cohort of age-matched historical non-HCT controls. Patients undergoing alloHCT will receive HCT in a US transplant center and be reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) using well-established CIBMT...
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
This clinical trial is evaluating whether addition of navtemadlin to ruxolitinib treatment will provide more clinical benefit than ruxolitinib alone for patients with Myelofibrosis who have a suboptimal response to ruxolitinib treatment alone. Subjects will start by receiving ruxolitinib alone in the run-in period. Those who demostrate a suboptimal response from ruxolitinib alone will then be ran...
A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)
The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia myelofibrosis (PET-MF) who have not previously received Janus kinase (JAK) inhibitor therapy.
Frequently Asked Questions About Myelofibrosis Clinical Trials
Are there myelofibrosis clinical trials near me?
Yes, there are 30 myelofibrosis clinical trials currently recruiting across 58+ cities in the United States, including New York, New York; Houston, Texas; Duarte, California. Browse the studies above to find one at a location convenient for you.
How do I join a myelofibrosis clinical trial?
To join a myelofibrosis clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are myelofibrosis clinical trials free?
Yes, participation in myelofibrosis clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of myelofibrosis treatments are being studied?
Current myelofibrosis clinical trials are testing a range of approaches across PHASE1 (19 studies), PHASE2 (13 studies), PHASE3 (2 studies), EARLY_PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 26 research organizations.
Is it safe to participate in myelofibrosis clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 16, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 16, 2026 · Data from ClinicalTrials.gov