Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Thalassemia Clinical Trials
Thalassemia clinical trials are recruiting across 26 cities. Here are the cities with the most active studies:
Thalassemia Trial Phases
10 research organizations are sponsoring thalassemia trials.
About Thalassemia
Thalassemia is an inherited blood disorder causing the body to produce abnormal or insufficient hemoglobin. Severe forms (thalassemia major) require regular blood transfusions. Treatment includes transfusions, iron chelation therapy, and potentially curative gene therapy.
Clinical trials are advancing new treatments for thalassemia. Currently, 12 studies are recruiting a combined 2,895 participants across the United States. Research is being conducted by 10 organizations including xCures, Celgene, University of California, San Francisco and 7 others.
2026 Thalassemia Research Landscape
As of August 2026, the thalassemia clinical trial landscape includes 12 actively recruiting studies across 26 cities in the United States. These studies are collectively seeking 2,895 participants, with an average enrollment target of 241 per study.
The research spans multiple phases of development: 4 studies are in PHASE3, 4 studies are in PHASE2, 1 study is in PHASE1. The presence of Phase 3 trials indicates that some thalassemia treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 10 different organizations, including xCures, Celgene, University of California, San Francisco, National Institute of Allergy and Infectious Diseases (NIAID), Genetix Biotherapeutics Inc., and 5 others.
Geographically, thalassemia trials are most concentrated in New York, New York (5 trials); Philadelphia, Pennsylvania (5 trials); Los Angeles, California (2 trials); Oakland, California (2 trials); Chicago, Illinois (2 trials) and 7 other cities.
Featured Thalassemia Studies
Highlighted recruiting studies for thalassemia, selected by enrollment size and research scope.
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
FLOWER is a completely virtual, nationwide, real-world observational study to collect, annotate, standardize, and report clinical data for rare diseases. Patients participate in the study by electronic consent (eConsent) and sign a medical records release to permit data collection. Medical records are accessed from institutions directly via eFax or paper fax, online from patient electronic medical...
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
A Phase 3b, open-label, single-arm, rollover study to evaluate the long-term safety of luspatercept, to the following participants: * Participants receiving luspatercept on a parent protocol at the time of their transition to the rollover study, who tolerate the protocol-prescribed regimen in the parent trial and, in the opinion of the investigator, may derive clinical benefit from continuing tre...
International Registry of Patients With Alpha Thalassemia
This is an international prospective registry of patients with Alpha thalassemia to understand the natural history of the disease and the outcomes of fetal therapies, with the overall goal of improving the prenatal management of patients with Alpha thalassemia.
Frequently Asked Questions About Thalassemia Clinical Trials
Are there thalassemia clinical trials near me?
Yes, there are 12 thalassemia clinical trials currently recruiting across 26+ cities in the United States, including New York, New York; Philadelphia, Pennsylvania; Los Angeles, California. Browse the studies above to find one at a location convenient for you.
How do I join a thalassemia clinical trial?
To join a thalassemia clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are thalassemia clinical trials free?
Yes, participation in thalassemia clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of thalassemia treatments are being studied?
Current thalassemia clinical trials are testing a range of approaches across PHASE3 (4 studies), PHASE2 (4 studies), PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 10 research organizations.
Is it safe to participate in thalassemia clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated August 30, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated August 30, 2026 · Data from ClinicalTrials.gov