Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia
The main purpose of this study is to evaluate the efficacy and safety of M281 in participants with warm autoimmune hemolytic anemia (wAIHA)....
A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia
The purpose of this study is to evaluate efficacy and safety of ianalumab compared to placebo in patients with warm autoimmune hemolytic anemia, who failed at least one line of treatment....
Top Cities for Paroxysmal Nocturnal Hemoglobinuria Clinical Trials
Paroxysmal Nocturnal Hemoglobinuria clinical trials are recruiting across 19 cities. Here are the cities with the most active studies:
About Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired blood disease where the immune system destroys red blood cells, causing dark-colored urine, fatigue, and blood clots. It is caused by a genetic mutation in blood stem cells. Treatment includes complement inhibitors like eculizumab.
Clinical trials are advancing new treatments for paroxysmal nocturnal hemoglobinuria. Currently, 2 studies are recruiting a combined 201 participants across the United States. Research is being conducted by 2 organizations including Janssen Research & Development, LLC, Novartis Pharmaceuticals.
2026 Paroxysmal Nocturnal Hemoglobinuria Research Landscape
As of March 2026, the paroxysmal nocturnal hemoglobinuria clinical trial landscape includes 2 actively recruiting studies across 19 cities in the United States. These studies are collectively seeking 201 participants, with an average enrollment target of 101 per study.
Research is being led by 2 different organizations, including Janssen Research & Development, LLC, Novartis Pharmaceuticals.
Geographically, paroxysmal nocturnal hemoglobinuria trials are most concentrated in Aurora, Colorado (2 trials); Fountain Valley, California (1 trial); Los Angeles, California (1 trial); Riverside, California (1 trial); Whittier, California (1 trial) and 7 other cities.
Featured Paroxysmal Nocturnal Hemoglobinuria Studies
Highlighted recruiting studies for paroxysmal nocturnal hemoglobinuria, selected by enrollment size and research scope.
Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia
The main purpose of this study is to evaluate the efficacy and safety of M281 in participants with warm autoimmune hemolytic anemia (wAIHA).
A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia
The purpose of this study is to evaluate efficacy and safety of ianalumab compared to placebo in patients with warm autoimmune hemolytic anemia, who failed at least one line of treatment.
Frequently Asked Questions About Paroxysmal Nocturnal Hemoglobinuria Clinical Trials
Are there paroxysmal nocturnal hemoglobinuria clinical trials near me?
Yes, there are 2 paroxysmal nocturnal hemoglobinuria clinical trials currently recruiting across 19+ cities in the United States, including Aurora, Colorado; Fountain Valley, California; Los Angeles, California. Browse the studies above to find one at a location convenient for you.
How do I join a paroxysmal nocturnal hemoglobinuria clinical trial?
To join a paroxysmal nocturnal hemoglobinuria clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are paroxysmal nocturnal hemoglobinuria clinical trials free?
Yes, participation in paroxysmal nocturnal hemoglobinuria clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of paroxysmal nocturnal hemoglobinuria treatments are being studied?
Current paroxysmal nocturnal hemoglobinuria clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 2 research organizations.
Is it safe to participate in paroxysmal nocturnal hemoglobinuria clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov