Cleveland, OHIO5 Active Studies

Myelofibrosis Clinical Trials in Cleveland, OHIO

Find 5 actively recruiting myelofibrosis clinical trials in Cleveland, OHIO. Connect with local research sites and explore new treatment options.

5
Active Trials
5
Sponsors
345
Enrolling

Recruiting Myelofibrosis Studies in Cleveland

RecruitingCleveland, OHIONCT05320198

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

This phase 1b/2a open-label study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of DISC-0974 as well as categorize the effects on anemia response in subjects with myelofi...

150 participants
Disc Medicine, Inc
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RecruitingCleveland, OHIONCT05980806

A Study of Selinexor Monotherapy in Subjects with JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

The main purpose of this study with corresponding optional expansion is to evaluate the efficacy of selinexor in JAKi-naïve participants with myelofibrosis (MF) and moderate thrombocytopenia based on ...

118 participants
Karyopharm Therapeutics Inc
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RecruitingCleveland, OHIONCT06773195

A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

The researchers are doing this study to find out whether the combination of ruxolitinib and ulixertinib is a safe and effective treatment for people with myelofibrosis. The researchers will test diffe...

37 participants
Memorial Sloan Kettering Cancer Center
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RecruitingCleveland, OHIONCT05835466

Reparixin in Patients With Myelofibrosis Myeloproliferative Neoplasms Research Consortium (MPN-RC 120)

This is an open label, phase II study to assess the efficacy, safety, and tolerability of Reparixin in patients with DIPSS intermediate-2, or high-risk primary myelofibrosis (PMF), post essential thro...

26 participants
Icahn School of Medicine at Mount Sinai
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RecruitingCleveland, OHIONCT05467800

Study of Canakinumab in Patients With Myelofibrosis

This is an open label, multicenter, phase 2 trial of Canakinumab in patients with primary myelofibrosis (PMF), post essential thrombocythemia/polycythemia vera related MF (Post ET/PV MF). Eligible pat...

14 participants
John Mascarenhas
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About Myelofibrosis Clinical Trials in Cleveland

Myelofibrosis is a serious bone marrow disorder that disrupts normal blood cell production, leading to extensive scarring in the bone marrow. It can cause severe anemia, weakness, and an enlarged spleen. Treatment includes JAK inhibitors, blood transfusions, and stem cell transplant.

There are currently 5 myelofibrosis clinical trials recruiting participants in Cleveland, OHIO. These studies are seeking a combined 345 participants. Research is being sponsored by Disc Medicine, Inc, Karyopharm Therapeutics Inc, Memorial Sloan Kettering Cancer Center and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Myelofibrosis Clinical Trials in Cleveland — FAQ

Are there myelofibrosis clinical trials in Cleveland?

Yes, there are 5 myelofibrosis clinical trials currently recruiting in Cleveland, OHIO. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Cleveland?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Cleveland research site will contact you about next steps.

Are clinical trials in Cleveland free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Cleveland studies also compensate for your time and travel.

What myelofibrosis treatments are being tested?

The 5 active trials in Cleveland are testing new therapies including novel drugs, biologics, and treatment approaches for myelofibrosis.

Data updated March 2, 2026 from ClinicalTrials.gov