17 Type 2 Diabetes Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Type 2 Diabetes Studies in Birmingham

NCT06957028Recruiting

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

The goal of this clinical trial is to use continuous glucose monitoring (CGM) to quickly detect and manage high blood sugar in pregnant women, early in pregnancy. The main questions it aims to answer ...

Birmingham, ALNA6,000 participantsJaeb Center for Health Research

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NCT07032844Recruiting

Advancing Diabetes Management for People With Physical Disabilities Optimally Through Primary Care-Based Telehealth (ADDOPT)

The purpose of the study is to compare 2 primary care based telehealth interventions- 1) digital health coaching and 2) remote patient monitoring for improving glycemic (blood sugar levels) control an...

Birmingham, ALNA5,000 participantsUniversity of Alabama at Birmingham

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NCT06525259Recruiting

DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic ...

Birmingham, AL3,600 participantsGeorge Washington University

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NCT07662213Recruiting

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequatel...

Birmingham, ALPHASE31,200 participantsAstraZeneca

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NCT06628908Recruiting

Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy

The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN)....

Birmingham, ALPHASE31,100 participantsVertex Pharmaceuticals Incorporated

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NCT07662044Recruiting

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron alone or in combination with dapagliflozin compared with placebo in adults with type 2 diabetes mellitus...

Birmingham, ALPHASE3800 participantsAstraZeneca

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NCT07231419Recruiting

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine in participants with pain associated with diabetic peripheral neuropathy (DPN)....

Birmingham, ALPHASE3734 participantsVertex Pharmaceuticals Incorporated

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NCT07533175Recruiting

AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. There are 2 study treatments in this study ...

Birmingham, ALPHASE3630 participantsNovo Nordisk A/S

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NCT07754461Recruiting

A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar

This study aims to find out whether a study medicine called survodutide helps people control their blood sugar. Adults who live with type 2 diabetes and with a body mass index (BMI) of 23 kg/m2 or hig...

Birmingham, ALPHASE3600 participantsBoehringer Ingelheim

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NCT06628453Recruiting

CGM for Management of Type 2 Diabetes in Pregnancy

The goal of this clinical trial is to learn if continuous glucose monitoring works better than self-monitoring of blood glucose (fingersticks) to treat type 2 diabetes in pregnancy. It will also learn...

Birmingham, ALNA564 participantsUniversity of Alabama at Birmingham

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NCT07668388Recruiting

A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Part...

Birmingham, ALPHASE2300 participantsNovo Nordisk A/S

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NCT07340320Recruiting

A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus

This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin...

Birmingham, ALPHASE2240 participantsCorxel Pharmaceuticals

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NCT04055428Recruiting

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. N...

Birmingham, ALPHASE2200 participantsUniversity of Alabama at Birmingham

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NCT07285018Recruiting

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain

The purpose of this study is to test the safety and efficacy of study drug LY4065967 for the treatment of diabetic peripheral neuropathic pain (DPNP). This trial is part of the chronic pain master pro...

Birmingham, ALPHASE2150 participantsEli Lilly and Company

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NCT03403686Recruiting

Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)

Results from large clinical trials demonstrate a strong association between lipid abnormalities and progression of the most common microvascular complication, diabetic retinopathy (DR). We found that ...

Birmingham, AL104 participantsUniversity of Alabama at Birmingham

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NCT07502508Recruiting

Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy

This is a phase 2 randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of icovamenib in participants with Type 2 Diabetes (T2D) not achieving glycemic targets despite O...

Birmingham, ALPHASE260 participantsBiomea Fusion Inc.

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NCT06902077Recruiting

A Low-Carb Approach to Treat Type 2 Diabetes in Pediatric Patients

The purpose of this project is to test the effect of a low carb diet compared to standard carb diet among adolescents with T2D over a 24-week period....

Birmingham, ALNA40 participantsUniversity of Alabama at Birmingham

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About Type 2 Diabetes Clinical Trials in Birmingham

Type 2 diabetes is a chronic metabolic condition affecting over 37 million Americans, characterized by insulin resistance and progressive loss of beta-cell function. While metformin remains the first-line treatment, the treatment landscape has expanded dramatically with GLP-1 receptor agonists (semaglutide, tirzepatide), SGLT2 inhibitors (empagliflozin, dapagliflozin), and dual GIP/GLP-1 agonists showing both glycemic and cardiovascular benefits. Clinical trials are now exploring triple-hormone agonists, oral GLP-1 formulations, islet cell regeneration therapies, and precision medicine approaches that tailor treatment to individual metabolic profiles. Patients with uncontrolled HbA1c on current medications, those with diabetic complications, or newly diagnosed patients may qualify for enrollment.

There are currently 17 type 2 diabetes clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 21,322 participants. Research is being sponsored by Jaeb Center for Health Research, University of Alabama at Birmingham, George Washington University and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Type 2 Diabetes Clinical Trials in Birmingham — FAQ

Are there type 2 diabetes clinical trials in Birmingham?

Yes, there are 17 type 2 diabetes clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What type 2 diabetes treatments are being tested?

The 17 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for type 2 diabetes.

Data updated September 1, 2026 from ClinicalTrials.gov