Birmingham, ALABAMA5 Active Studies

Depression Clinical Trials in Birmingham, ALABAMA

Find 5 actively recruiting depression clinical trials in Birmingham, ALABAMA. Connect with local research sites and explore new treatment options.

5
Active Trials
5
Sponsors
4,112
Enrolling

Recruiting Depression Studies in Birmingham

RecruitingBirmingham, ALABAMANCT06433635

Sequential Multiple Assignment Randomized Trial for Bipolar Depression

This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic tri...

2,726 participants
Massachusetts General Hospital
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RecruitingBirmingham, ALABAMANCT06559306

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant i...

752 participants
Janssen Research & Development, LLC
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RecruitingBirmingham, ALABAMANCT06308653

Psilocybin for Major Depressive Disorder (MDD)

Approximately 240 eligible adult participants (≥18 years old) who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) criteria for Major Depressive Disorder (MDD) will be enrolled. P...

240 participants
Usona Institute
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RecruitingBirmingham, ALABAMANCT06633016

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

The goal of this clinical trial is to learn if ABX-002 added to an existing antidepressant treatment will benefit depression symptoms in adults with moderate to severe major depressive disorder who ha...

230 participants
Autobahn Therapeutics, Inc.
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RecruitingBirmingham, ALABAMANCT06547489

GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder

The goal of this clinical trial is to learn if GATE-251 works to treat depression in adults. It will also learn about the safety of GATE-251. The main questions it aims to answer are: Does GATE-251 r...

164 participants
Syndeio Biosciences, Inc
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About Depression Clinical Trials in Birmingham

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 5 depression clinical trials recruiting participants in Birmingham, ALABAMA. These studies are seeking a combined 4,112 participants. Research is being sponsored by Massachusetts General Hospital, Janssen Research & Development, LLC, Usona Institute and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Birmingham — FAQ

Are there depression clinical trials in Birmingham?

Yes, there are 5 depression clinical trials currently recruiting in Birmingham, ALABAMA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What depression treatments are being tested?

The 5 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated March 2, 2026 from ClinicalTrials.gov