27 Depression Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Depression Studies in Boston

NCT05800925Recruiting

Triage Survey for Psychiatry Research Eligibility

TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials....

Boston, MA20,000 participantsAdams Clinical

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NCT04092010Recruiting

Improving Preschool Outcomes by Addressing Maternal Depression in Head Start

Within a research network of Head Start centers in Massachusetts, an efficacy trial of a stepped-care intervention (SCI) to address maternal depression, using intervention components that both prevent...

Boston, MANA388 participantsBrown University

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NCT03276793Recruiting

Brain Connectivity in Depression

This study originally included 140 subjects with medication-refractory depression undergoing 10 Hz transcranial magnetic stimulation (10Hz-TMS) to the left dorsal lateral prefrontal cortex (DLPFC), wi...

Boston, MANA260 participantsBrigham and Women's Hospital

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NCT06976697Recruiting

Home-Based tDCS Treatment Of Major Depressive Disorder

The REACH-tDCS study will evaluate the safety and efficacy of a noninvasive, at-home self-administered Sooma tDCS brain stimulation treatment for Major Depressive Disorder. The study uses randomized, ...

Boston, MANA200 participantsSooma Medical Inc

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NCT06911112Recruiting

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

Boston, MAPHASE3200 participantsNeurocrine Biosciences

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NCT06786624Recruiting

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

Boston, MAPHASE3200 participantsNeurocrine Biosciences

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NCT06376734Recruiting

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be ...

Boston, MAPHASE2180 participantsBrigham and Women's Hospital

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NCT05570812Recruiting

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of ...

Boston, MAPHASE2120 participantsMassachusetts General Hospital

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NCT05573074Recruiting

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression. Near infrared energy is like li...

Boston, MANA120 participantsNYU Langone Health

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NCT07082998Recruiting

Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms...

Boston, MANA120 participantsMassachusetts General Hospital

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NCT05624931Recruiting

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV. However, posttraumatic stres...

Boston, MANA118 participantsBoston University Charles River Campus

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NCT05450432Recruiting

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketa...

Boston, MAPHASE4100 participantsMassachusetts General Hospital

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NCT06423430Recruiting

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjuncti...

Boston, MANA100 participantsAbbott Medical Devices

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NCT07475845Recruiting

Teenthrive 2: Treatments for Improving Mood in Teens

In this study, we will conduct a pilot RCT of a yoga-based intervention (YBI) vs. group cognitive-behavioral therapy (gCBT) at two sites. We will recruit 48 adolescent participants each in Columbus, O...

Boston, MANA96 participantsButler Hospital

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NCT05617495Recruiting

Mindfulness-Based fMRI Neurofeedback for Depression

In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promisin...

Boston, MANA90 participantsColumbia University

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NCT07217561Recruiting

Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health

Doulas are trained individuals who offer informational, emotional, and physical support to their pregnant, birthing, and postpartum clients. The goal of this clinical trial is to learn if a new interv...

Boston, MANA90 participantsBeth Israel Deaconess Medical Center

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NCT06878859Recruiting

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized...

Boston, MANA80 participantsMassachusetts General Hospital

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NCT06238700Recruiting

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

This study aims to identify how enhanced allopregnanolone activity (via pregnenolone) affects behavior and neurobiology that may underlie perimenopausal depression....

Boston, MANA80 participantsBeth Israel Deaconess Medical Center

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NCT06289010Recruiting

Neural Mechanisms of Family-Focused Treatment for Youth Depression

The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as pred...

Boston, MANA80 participantsBoston University Charles River Campus

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NCT05523817Recruiting

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal wi...

Boston, MANA80 participantsMassachusetts General Hospital

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NCT07230990Recruiting

Mechanisms Of Orbitofrontal Stimulation in Depression

The orbitofrontal cortex (OFC), a region involved in emotional regulation, decision making, and reward processing, is a key area linked to antidepressant response. This study tests whether noninvasive...

Boston, MANA80 participantsSubha Subramanian

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NCT06968390Recruiting

Accelerated TMS for Perinatal Depression

We are studying a treatment for depression called accelerated Transcranial Magnetic Stimulation (TMS) among pregnant and postpartum individuals. TMS is a focal, non-invasive form of brain stimulation ...

Boston, MANA24 participantsBrigham and Women's Hospital

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NCT05393622Recruiting

Brain Stimulation for Severe Depression

Chronic intracalvarial cortical stimulation is a minimally invasive method involving the neurosurgical placement of an electrode above the inner table of the skull. Over time, intracalvarial cortical ...

Boston, MANA20 participantsInner Cosmos Inc

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NCT07563868Recruiting

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individu...

Boston, MANA20 participantsMassachusetts General Hospital

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NCT07032363Recruiting

Implementing Depression and Adherence Treatment

The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The mai...

Boston, MANA10 participantsUniversity of Miami

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NCT06599099Recruiting

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

This study is only enrolling at Baylor College of Medicine. The other research locations listed serve to support data analysis only. This research study is to investigate the use of technology called...

Boston, MANA10 participantsWayne Goodman MD

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NCT04400266Recruiting

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination. The current research group conduc...

Boston, MAPHASE410 participantsMassachusetts General Hospital

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About Depression Clinical Trials in Boston

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 27 depression clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 22,876 participants. Research is being sponsored by Adams Clinical, Brown University, Brigham and Women's Hospital and 13 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Boston — FAQ

Are there depression clinical trials in Boston?

Yes, there are 27 depression clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What depression treatments are being tested?

The 27 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated July 16, 2026 from ClinicalTrials.gov