15 Inflammatory Bowel Disease Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Inflammatory Bowel Disease Studies in Boston

NCT05781152Recruiting

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both. CD may be associated with abdominal cramps/pai...

Boston, MAPHASE4900 participantsConnecticut Children's Medical Center

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NCT03256240Recruiting

Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis

This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Cro...

Boston, MANA600 participantsWeill Medical College of Cornell University

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NCT07237516Recruiting

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

The goal of this observational study is to learn about how effective Zymfentra (IFX=dyyb) is when treating patients with Crohn's disease (CD) and ulcerative colitis (UC) Does Zymfentra lead to a reduc...

Boston, MA200 participantsUniversity of North Carolina, Chapel Hill

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NCT07168499Recruiting

Diet and Stress Management Combined With Advanced Therapy for Crohn's and Ulcerative Colitis

Inflammatory Bowel Disease (IBD), which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic, immune-mediated disease characterized by recurrent episodes of relapse. The goal of thi...

Boston, MANA160 participantsMassachusetts General Hospital

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NCT04844606Recruiting

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks ...

Boston, MAPHASE3150 participantsEli Lilly and Company

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NCT05987852Recruiting

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric p...

Boston, MANA126 participantsNorthwestern University

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NCT05923073Recruiting

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

The purpose of this study is to evaluate the clinical and endoscopic efficacy of guselkumab in pediatric participants with Crohn's Disease (CD) at the end of maintenance therapy (Week 52) among partic...

Boston, MAPHASE3120 participantsJanssen Research & Development, LLC

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NCT04779320Recruiting

A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe Crohn's disease will be treated with vedoliz...

Boston, MAPHASE3120 participantsTakeda

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NCT04508088Recruiting

Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease

The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigat...

Boston, MA92 participantsMassachusetts General Hospital

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NCT05509777Recruiting

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention. The purpose of the mirikizumab study is to evaluate efficacy, safety...

Boston, MAPHASE390 participantsEli Lilly and Company

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NCT05332639Recruiting

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-Crohn's) tool on behaviors and biomarkers associated wit...

Boston, MANA80 participantsMassachusetts General Hospital

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NCT04331639Recruiting

High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy

The investigators will be administering oral high dose interval vitamin D, concurrently when participants are receiving biologic therapy for their inflammatory bowel disease. The investigators will be...

Boston, MA50 participantsBoston Children's Hospital

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NCT06655415Recruiting

Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

First-degree relatives of people with inflammatory bowel disease ("IBD," including Crohn's disease and ulcerative colitis) have an increased risk for developing IBD themselves. This study will follow ...

Boston, MA50 participantsMassachusetts General Hospital

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NCT05287126Recruiting

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years ...

Boston, MAPHASE236 participantsPfizer

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NCT04263831Recruiting

Low Dose IL-2 for the Treatment of Crohn's Disease

The purpose of this study is to determine the safety and maximum effective dose (MED) of Interleukin-2 in subjects with moderate-to-severe crohn's disease....

Boston, MAPHASE130 participantsBoston Children's Hospital

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About Inflammatory Bowel Disease Clinical Trials in Boston

Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract, primarily Crohn's disease and ulcerative colitis. It affects millions worldwide and can cause debilitating symptoms. Treatment includes anti-inflammatory drugs, immunosuppressants, biologics, and surgery.

There are currently 15 inflammatory bowel disease clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 2,804 participants. Research is being sponsored by Connecticut Children's Medical Center, Weill Medical College of Cornell University, University of North Carolina, Chapel Hill and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Inflammatory Bowel Disease Clinical Trials in Boston — FAQ

Are there inflammatory bowel disease clinical trials in Boston?

Yes, there are 15 inflammatory bowel disease clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What inflammatory bowel disease treatments are being tested?

The 15 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for inflammatory bowel disease.

Data updated October 17, 2026 from ClinicalTrials.gov