14 Sarcoma Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Sarcoma Studies in Boston

NCT03838718Recruiting

REtroperitoneal SArcoma Registry: an International Prospective Initiative

Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, an...

Boston, MA2,000 participantsFondazione IRCCS Istituto Nazionale dei Tumori, Milano

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NCT05653388Recruiting

Metastatic Leiomyosarcoma Biomarker Protocol

Leiomyosarcoma (LMS) is one of the most prevalent soft tissue sarcomas (STS) and can occur in various sites including soft tissue, uterus and retroperitoneal large vessels. Metastatic disease occurs i...

Boston, MA200 participantsUniversity of Michigan Rogel Cancer Center

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NCT06239272Recruiting

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

The study participant has been diagnosed with non-rhabdomyosarcoma (NRSTS). Primary Objectives Intermediate-Risk * To estimate the 3-year event-free survival for intermediate-risk patients treated ...

Boston, MAPHASE1139 participantsSt. Jude Children's Research Hospital

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NCT07377747Recruiting

Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma

The aim of the study is to collect prospective data on the treatment outcomes in patients with first localized, resectable recurrent retroperitoneal well-differentiated and/or dedifferentiated liposar...

Boston, MA100 participantsAustralia and New Zealand Sarcoma Association

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NCT01659203Recruiting

Proton or Photon RT for Retroperitoneal Sarcomas

This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigatio...

Boston, MAPHASE180 participantsMassachusetts General Hospital

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NCT06709495Recruiting

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

This research is being done to test a new drug called PEEL-224 in combination with two commercially available drugs, Vincristine and Temozolomide, and to determine how effective this combination of dr...

Boston, MAPHASE163 participantsDavid S Shulman, MD

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NCT05918640Recruiting

Lurbinectedin in FET-Fused Tumors

The purpose of this study is to find out if a drug called lurbinectedin (the "study drug") is safe and effective at treating people with recurrent or relapsed solid tumors, including Ewing sarcoma....

Boston, MAPHASE163 participantsChildren's Hospital of Philadelphia

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NCT07357519Recruiting

Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy)

This is a multi-center, non-randomized, open-label, dosimetry and dose-escalation, cohort-expansion study of LNTH-2403 administered to subjects with relapsed / refractory (R/R) osteosarcoma. This stud...

Boston, MAPHASE155 participantsLantheus Medical Imaging

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NCT07297979Recruiting

Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

The main objectives of this trial are to determine the recommended dose for expansion of xaluritamig (dose confirmation part only) and to determine the safety and tolerability of xaluritamig in adult,...

Boston, MAPHASE150 participantsAmgen

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NCT05019703Recruiting

Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study

This phase II trial studies the effect of atezolizumab and cabozantinib in treating adolescents and young adults with osteosarcoma that has come back (recurrent) or has spread to other places in the b...

Boston, MAPHASE240 participantsM.D. Anderson Cancer Center

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NCT07662239Recruiting

Bridging Adolescent and Young Adult Sarcoma Survivors With Personalized Oncology Exercise Service (AYA-ONE): A Pilot Intervention

This study will evaluate strategies to improve physical function and promote exercise and physical activity in adolescents and young adults (AYAs) with sarcoma. The study will assess the feasibility o...

Boston, MANA40 participantsDana-Farber Cancer Institute

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NCT05711615Recruiting

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

This phase I trial tests the safety, side effects, and best dose of combination therapy with liposomal doxorubicin and peposertib in treating patients with sarcoma that has spread from where it first ...

Boston, MAPHASE130 participantsNational Cancer Institute (NCI)

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NCT07467772Recruiting

Ph 2 Elacestrant in ER Positive Uterine Sarcomas

This study is to evaluate the efficacy and safety of elacestrant, in participants with advanced estrogen receptor (ER)-positive uterine sarcomas. The name of the study drug involved in this research s...

Boston, MAPHASE230 participantsDana-Farber Cancer Institute

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NCT06812052Recruiting

Short Course Radiation Treatment for Patients With Primary or Locally Recurrent Retroperitoneal Sarcoma Prior to Surgery

To determine the safety of moderately hypofractionated radiation in the treatment of primary and locally recurrent RPS, based on the evaluation of acute radiation-related toxicity profile of each part...

Boston, MAPHASE16 participantsBrigham and Women's Hospital

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About Sarcoma Clinical Trials in Boston

Sarcomas are rare cancers that arise in bone and soft tissues including muscle, fat, blood vessels, and connective tissue. There are more than 70 subtypes of sarcoma. Treatment usually involves surgery combined with radiation and/or chemotherapy.

There are currently 14 sarcoma clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 2,896 participants. Research is being sponsored by Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, University of Michigan Rogel Cancer Center, St. Jude Children's Research Hospital and 10 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sarcoma Clinical Trials in Boston — FAQ

Are there sarcoma clinical trials in Boston?

Yes, there are 14 sarcoma clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What sarcoma treatments are being tested?

The 14 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for sarcoma.

Data updated August 27, 2026 from ClinicalTrials.gov