21 HIV AIDS Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting HIV AIDS Studies in Chicago

NCT05848570Recruiting

Keeping it LITE: Exploring HIV Risk in Vulnerable Youth With Limited Interaction and Digital Health Intervention

Despite advances in HIV diagnostics, care and prevention strategies, infection rates among adolescent and young adult sexual and gender minorities (SGM) continue to rise in the United States (US). The...

Chicago, IL6,000 participantsHektoen Institute for Medical Research

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NCT05678556Recruiting

Effectiveness of Relationship Education for Reducing HIV Incidence Among Men Who Have Sex With Men

The purpose of this study is to upgrade an existing relationship education and HIV prevention program. This program is designed for gay, bisexual, queer, and transgender and non-binary people who part...

Chicago, ILNA5,000 participantsNorthwestern University

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NCT07044297Recruiting

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: * If taking MK-8527 once a month works to prevent HI...

Chicago, ILPHASE34,390 participantsMerck Sharp & Dohme LLC

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NCT06741631Recruiting

MyPEEPS LITE Trial

This study will use community-informed advertisements and messages through electronic methods to recruit and retain a large (N=3,200), diverse national sample of high-risk young men who have sex with ...

Chicago, ILNA3,200 participantsColumbia University

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NCT07473778Recruiting

Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention

The goal of this observational study is to generate real-life information on the use of lenacapavir (LEN, YEZTUGO®, (YTG)) for pre-exposure prophylaxis (PrEP) across diverse clinical settings in the U...

Chicago, IL3,000 participantsGilead Sciences

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NCT07293559Recruiting

Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

IMPAACT 2046/UPLIFT (Understanding Practices of Lactation and Infant Feeding decisions Together with women with HIV) is a multi-site, mixed-methods, observational cohort study. The purpose of the stud...

Chicago, IL1,150 participantsInternational Maternal Pediatric Adolescent AIDS Clinical Trials Group

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NCT02140255Recruiting

Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission

The study will explore the effects of early intensive antiretroviral therapy (ART) with or without a broadly neutralizing antibody (bNAb) on achieving HIV remission (HIV RNA below the limit of detecti...

Chicago, ILPHASE11,120 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05723653Recruiting

Hybrid Type I Effectiveness-Implementation Trial of a Social Network Support Intervention

The goal of this Hybrid Type I effectiveness-implementation trial is to test an evidence-based, flexible, and tailored intervention that leverages existing social network members to promote retention ...

Chicago, ILNA900 participantsUniversity of Chicago

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NCT06266416Recruiting

IMARA for Black Male Caregivers and Girls Empowerment (IMAGE)

The scientific premise of this research is that individual, interpersonal, and structural factors impact Black girls' sexual reproductive health outcomes (sexually transmitted infection (STI) and Huma...

Chicago, ILNA612 participantsUniversity of Illinois at Chicago

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NCT06477588Recruiting

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

The goal of this clinical trial is to compare two interventions - Health Navigation and Health Navigation Plus among individuals who have been impacted by the criminal legal system. The main question...

Chicago, ILNA350 participantsUniversity of Chicago

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NCT06263426Recruiting

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV....

Chicago, ILNA200 participantsJohns Hopkins University

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NCT06162897Recruiting

Case Management Dyad

The overall goal of this study is to test whether dyadic and focused case management will (1) improve financial wellbeing, (2) improve access to food, (3) increase linkage and retention rates for indi...

Chicago, ILNA180 participantsUniversity of Chicago

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NCT06894199Recruiting

Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men

The goal of this observational study is to learn about the pilot test of the employment program among young Black sexual minority men. The main question it aims to answer is: What is the feasibility ...

Chicago, IL132 participantsUniversity of Chicago

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NCT06550804Recruiting

Testing a Real-time Electronic Antiretroviral Adherence Monitoring Intervention

The investigators propose using an electronic adherence device that is basically a pill container that can alert when it is not opened at a scheduled time. The investigators will use this device to al...

Chicago, ILPHASE3126 participantsUniversity of Illinois at Chicago

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NCT06856174Recruiting

Menopausal HT for Women Living With HIV (HoT)

Women living with HIV have been shown to experience more frequent and severe hot flashes and night sweats (collectively known as vasomotor symptoms) as compared to women living without HIV. This corre...

Chicago, ILPHASE4105 participantsAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

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NCT07392372Recruiting

A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV

This study will test the safety and blood levels of the antibody BNT351 in people living without and with human immunodeficiency virus (HIV). This study will also test the anti-viral activity of BNT35...

Chicago, ILPHASE167 participantsBioNTech SE

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NCT06517693Recruiting

Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of the potent, broadly neutralizing anti-HIV monoclonal antibodies (mAb) PGT121.414.LS alone and in combination with VRC07...

Chicago, ILPHASE148 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05719441Recruiting

A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

A5388 is a phase II, two-arm, randomized, double-blind, placebo-controlled study that will enroll 48 antiretroviral therapy (ART)-naïve adults with acute HIV infection (AHI) in order to determine whet...

Chicago, ILPHASE248 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06071767Recruiting

Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

The purpose of this study is to evaluate the safety, tolerability, and efficacy of therapeutic vaccination with chimpanzee adenovirus ChAdOx1- and poxvirus modified vaccinia Ankara (MVA)-vectored cons...

Chicago, ILPHASE136 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05077527Recruiting

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

This phase I trial evaluates the side effects and usefulness of axicabtagene clioleucel (a CAR-T therapy) and find out what effect, if any, it has on treating patients with HIV-associated aggressive B...

Chicago, ILPHASE120 participantsAIDS Malignancy Consortium

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NCT07342491Recruiting

Dasatinib for HIV-1 Reservoir Reduction

This study will test if the medicine dasatinib can lower the hidden amount of HIV in the body, called the HIV "reservoir." It will also check if dasatinib is safe and easy to take for people living wi...

Chicago, ILPHASE114 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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About HIV AIDS Clinical Trials in Chicago

HIV (human immunodeficiency virus) attacks the immune system and, if untreated, can lead to AIDS (acquired immunodeficiency syndrome). Antiretroviral therapy (ART) can control the virus and prevent transmission. Research continues to pursue a functional cure, long-acting therapies, and preventive vaccines.

There are currently 21 hiv aids clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 26,698 participants. Research is being sponsored by Hektoen Institute for Medical Research, Northwestern University, Merck Sharp & Dohme LLC and 10 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

HIV AIDS Clinical Trials in Chicago — FAQ

Are there hiv aids clinical trials in Chicago?

Yes, there are 21 hiv aids clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What hiv aids treatments are being tested?

The 21 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for hiv aids.

Data updated July 16, 2026 from ClinicalTrials.gov