8 COVID-19 Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting COVID-19 Studies in Chicago

NCT04278404Recruiting

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the m...

Chicago, IL5,000 participantsDuke University

View Study Details

NCT06631287Recruiting

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertio...

Chicago, ILPHASE3550 participantsWes Ely

View Study Details

NCT06825819Recruiting

Dysbiosis & Long COVID

The SARS-CoV-2 virus causes COVID-19, which ranges from mild initial symptoms to severe multi-organ dysfunction. While some patients recover to their baseline states, others develop a long COVID, or p...

Chicago, IL400 participantsUniversity of Chicago

View Study Details

NCT06008860Recruiting

A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection

The study team proposes to evaluate the efficacy of Astepro® 0.15% nasal spray in treating SARS-CoV-2 infection in adults through a pilot and feasibility clinical trial at the University of Chicago....

Chicago, ILPHASE4280 participantsUniversity of Chicago

View Study Details

NCT03808922Recruiting

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19....

Chicago, ILPHASE3274 participantsAnsun Biopharma, Inc.

View Study Details

NCT05261139Recruiting

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and ef...

Chicago, ILPHASE3160 participantsPfizer

View Study Details

NCT06850350Recruiting

Cognitive-Sensorimotor Function in Long-COVID

Growing evidence indicates that many people who have chronic post-acute sequelae of SARS-CoV-2 infection (PASC) will experience ongoing neurological and musculoskeletal impairment that can affect gait...

Chicago, IL136 participantsVA Office of Research and Development

View Study Details

NCT04442191Recruiting

Convalescent Plasma as a Possible Treatment for COVID-19

Patients who are ill with COVID-19 may benefit from receiving convalescent plasma infusions containing antibodies from donors who have recovered from the disease and are proven to no longer be infecte...

Chicago, ILPHASE250 participantsUniversity of Illinois at Chicago

View Study Details

About COVID-19 Clinical Trials in Chicago

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that primarily affects the respiratory system. Long COVID (PASC) involves persistent symptoms weeks or months after initial infection. Treatment includes antiviral medications, monoclonal antibodies, and supportive care.

There are currently 8 covid-19 clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 6,850 participants. Research is being sponsored by Duke University, Wes Ely, University of Chicago and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

COVID-19 Clinical Trials in Chicago — FAQ

Are there covid-19 clinical trials in Chicago?

Yes, there are 8 covid-19 clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What covid-19 treatments are being tested?

The 8 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for covid-19.

Data updated July 16, 2026 from ClinicalTrials.gov