25 Multiple Sclerosis Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Multiple Sclerosis Studies in Chicago

NCT05877963Recruiting

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

The primary purpose of this phase 3b study is to assess the efficacy of a modified regimen of ublituximab as measured by T1 Gadolinium (Gd)-enhancing lesions and pharmacokinetics in participants with ...

Chicago, ILPHASE3800 participantsTG Therapeutics, Inc.

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NCT05614739Recruiting

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435 by itself or when it is combined with other standard medicines that treat cancer. LOXO-435...

Chicago, ILPHASE1535 participantsEli Lilly and Company

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NCT07216326Recruiting

Our Voices Matter: Intervention for Depression in Youth

Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD). SRD manifests ...

Chicago, ILNA300 participantsAnn & Robert H Lurie Children's Hospital of Chicago

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NCT06408259Recruiting

Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

The purpose of this study is to evaluate the effectiveness, safety, tolerability, drug levels and drug effects of ozanimod compared to fingolimod in children and adolescents with relapsing remitting m...

Chicago, ILPHASE3194 participantsCelgene

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NCT06313593Recruiting

A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms

This study is being conducted to assess the Safety, Tolerability, and Pharmacokinetics of INCB160058 in Participants With Myeloproliferative Neoplasms....

Chicago, ILPHASE1186 participantsIncyte Corporation

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NCT05051618Recruiting

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (...

Chicago, ILNA146 participantsUniversity of Illinois at Chicago

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NCT06206486Recruiting

The Gut Microbiome and Serum Metabolites As a Biological Mechanism Underlying Pain in Kidney Transplantation

Study Summary Nearly half (47%) of people with end-stage kidney disease (ESKD) whose kidney function is restored after kidney transplantation experience chronic pain compared to 19% of adults in the U...

Chicago, IL133 participantsUniversity of Illinois at Chicago

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NCT05285891Recruiting

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

This study is a prospective, multi-center, randomized, double blinded, placebo-controlled study of OCR treatment-discontinuation in patients with early RMS. All eligible participants will be initiated...

Chicago, ILPHASE4123 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT07008118Recruiting

A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

This study is being conducted to evaluate the safety and tolerability of INCA035784 in participants with myeloproliferative neoplasms....

Chicago, ILPHASE1120 participantsIncyte Corporation

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NCT06341023Recruiting

Functional Balance Intervention in Multiple Sclerosis

This project involves two sub-parts: Study 1: Effect of lab-based Functional Balance Intervention (FBI) for physical and cognitive symptoms of Multiple Sclerosis. Study 2: Feasibility of home-based ...

Chicago, ILNA120 participantsUniversity of Illinois at Chicago

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NCT07207148Recruiting

People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists

The primary outcome measure is PIRA (progression independent of relapse activity), based primarily on clinical assessment, dichotomized as present or not. For Aim 1, the cohort, patient-derived disab...

Chicago, IL100 participantsNorthwestern University

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NCT07355387Recruiting

Home Based Functional Balance Intervention for Multiple Sclerosis

The study involves a two-arm, Phase 1, randomized controlled clinical trial designed to establish the feasibility and effects of a Functional Balance Intervention (FBI) on physical and cognitive funct...

Chicago, ILNA75 participantsUniversity of Illinois at Chicago

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NCT07090889Recruiting

Study of KM-023 in Healthy Volunteers and Patients With Olmsted Syndrome.

The trial is conducted in order to assess the safety of KM-023 and to observe what effects, both beneficial and adverse, it has on the body, and the way the body absorbs and eliminates KM-023, first i...

Chicago, ILPHASE164 participantsOrvida Pharma (formerly Kamari Pharma)

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NCT06395415Recruiting

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

Electronic Nicotine Delivery Systems (ENDS) use remains prevalent among young adults, and many have high interest in quitting, yet research on effective intervention is lacking. A mobile health (mHeal...

Chicago, ILNA46 participantsUniversity of Chicago

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NCT05985161Recruiting

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNST, or another solid tumor that makes a h...

Chicago, ILPHASE245 participantsMemorial Sloan Kettering Cancer Center

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NCT06516458Recruiting

Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis

The purpose of this study is to develop a measurement of walking quality, called Gait Deviation Index (GDI) for people with Multiple Sclerosis (MS)....

Chicago, IL40 participantsShirley Ryan AbilityLab

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NCT07225361Recruiting

Ublituximab (Briumvi) for Early Forms of Relapsing Multiple Sclerosis

In this prospective, open-label, single-arm, single-institution trial, the investigators will accomplish the following two aims: 1. study the safety and tolerability of Ublituximab (Briumvi) twice an...

Chicago, ILPHASE440 participantsNorthwestern University

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NCT06912087Recruiting

Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC

This Phase I clinical trial evaluates the safety, tolerability, and optimal dosing of Zanzalintinib in combination with Pembrolizumab and Cetuximab in patients with recurrent and/or metastatic squamou...

Chicago, ILPHASE136 participantsUniversity of Chicago

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NCT06410261Recruiting

Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device

Approximately 50% of people with multiple sclerosis (MS) use a wheelchair within 30 years of the initial diagnosis. Wheelchair use in MS is often associated with fatigue as a consequence of muscle wea...

Chicago, ILNA24 participantsUniversity of Illinois at Chicago

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NCT06390930Recruiting

Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population. The breathing intervention, known as Acute Int...

Chicago, ILNA22 participantsShirley Ryan AbilityLab

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NCT06276634Recruiting

Intermittent Hypoxia in Persons With Multiple Sclerosis

This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low le...

Chicago, ILNA21 participantsShirley Ryan AbilityLab

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NCT06291987Recruiting

Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation

The purpose of this research is to gather information on the safety and effectiveness determining maximum tolerated dose (MTD) of ruxolitinib in combination with ivosidenib in IDH1-mutated advanced-ph...

Chicago, ILPHASE118 participantsUniversity of Chicago

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NCT07132775Recruiting

Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

The purpose of this study is to to explore the safety and efficacy of the EXOPULSE Mollii suit, a full-body electrostimulation suit, for individuals with neurological or neuromuscular conditions that ...

Chicago, ILNA15 participantsShirley Ryan AbilityLab

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NCT06653426Recruiting

The NaBu Effect on Menstruation in Women

The purpose of this study is to evaluate the effect of once-daily Sodium butyrate (NaBu) on menstrual symptoms in women. The investigators posit that the use of NaBu will reduce menstrual symptoms aft...

Chicago, ILNA15 participantsMagdy Milad, MD

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NCT07111182Recruiting

Intraoperative Fluorescence-Guided Aspirate Tissue Monitoring of 5-ALA During Brain Tumor Surgery

Gliomas are tumors that occur in all ages; they include the most common malign primary central nervous system tumors in developed countries. Gliomas are often aggressive, and their recommended treatme...

Chicago, ILNA8 participantsUniversity of Illinois at Chicago

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About Multiple Sclerosis Clinical Trials in Chicago

Multiple sclerosis (MS) is an autoimmune disease where the immune system attacks the protective covering of nerve fibers, causing communication problems between the brain and body. Symptoms vary widely and can include vision problems, fatigue, and mobility issues. Disease-modifying therapies have significantly improved outcomes.

There are currently 25 multiple sclerosis clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 3,226 participants. Research is being sponsored by TG Therapeutics, Inc., Eli Lilly and Company, Ann & Robert H Lurie Children's Hospital of Chicago and 10 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Multiple Sclerosis Clinical Trials in Chicago — FAQ

Are there multiple sclerosis clinical trials in Chicago?

Yes, there are 25 multiple sclerosis clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What multiple sclerosis treatments are being tested?

The 25 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for multiple sclerosis.

Data updated July 16, 2026 from ClinicalTrials.gov