8 ALS Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting ALS Studies in Chicago

NCT05966038Recruiting

ALS/MND Natural History Study Data Repository

This is a data repository for multi-site multi-protocol clinic-based Natural History Study of ALS and Other Motor Neuron Disorders (MND). All people living with ALS or other MNDs who attend clinics a...

Chicago, IL5,000 participantsMassachusetts General Hospital

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NCT05137665Recruiting

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information ...

Chicago, IL1,000 participantsTarget ALS Foundation, Inc.

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NCT07322003Recruiting

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

The goal of this clinical trial is to learn if the drug pridopidine works to treat amyotrophic lateral sclerosis in adults. It will also help to learn about the safety of pridopidine. The main questio...

Chicago, ILPHASE3500 participantsPrilenia

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NCT07161999Recruiting

Study of COYA 302 for the Treatment of ALS

The ALSTARS trial will be conducted across 20-25 sites in the US and Canada, and will evaluate the safety and efficacy of an investigational treatment called COYA 302 for adults with Amyotrophic Later...

Chicago, ILPHASE2120 participantsCoya Therapeutics

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NCT06189781Recruiting

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly. This is especially true in patient...

Chicago, ILPHASE490 participantsUniversity of California, Los Angeles

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NCT07433023Recruiting

tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy

This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy. Participants will complete a 16-week training program with weekly se...

Chicago, ILPHASE280 participantsShirley Ryan AbilityLab

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NCT07434492Recruiting

Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy

This is an intervention study to investigate the impact of a smart ankle-foot orthosis (AFO) on mobility outcomes in children with Cerebral Palsy. Participants will complete a three phase protocol inc...

Chicago, ILPHASE260 participantsShirley Ryan AbilityLab

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NCT05067179Recruiting

Analysis of Human ALS Tissues and Registry of ALS Patients

Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig's Disease, is a progressive, terminal condition of muscle weakness that is associated with degeneration of neurons in the spinal co...

Chicago, IL40 participantsUniversity of Illinois at Chicago

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About ALS Clinical Trials in Chicago

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons controlling voluntary muscle movement. Also known as Lou Gehrig's disease, it leads to increasing paralysis. Research is actively pursuing disease-modifying treatments and gene therapies.

There are currently 8 als clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 6,890 participants. Research is being sponsored by Massachusetts General Hospital, Target ALS Foundation, Inc., Prilenia and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

ALS Clinical Trials in Chicago — FAQ

Are there als clinical trials in Chicago?

Yes, there are 8 als clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What als treatments are being tested?

The 8 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for als.

Data updated July 16, 2026 from ClinicalTrials.gov