Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for ALS Clinical Trials
ALS clinical trials are recruiting across 167 cities. Here are the cities with the most active studies:
ALS Trial Phases
78 research organizations are sponsoring als trials.
About ALS
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons controlling voluntary muscle movement. Also known as Lou Gehrig's disease, it leads to increasing paralysis. Research is actively pursuing disease-modifying treatments and gene therapies.
Clinical trials are advancing new treatments for als. Currently, 100 studies are recruiting a combined 774,307 participants across the United States. Research is being conducted by 78 organizations including University of Wisconsin, Madison, University of Southern California, University of Central Florida and 75 others.
2026 ALS Research Landscape
As of July 2026, the als clinical trial landscape includes 100 actively recruiting studies across 167 cities in the United States. These studies are collectively seeking 774,307 participants, with an average enrollment target of 7,743 per study.
The research spans multiple phases of development: 35 studies are in NA, 10 studies are in PHASE3, 4 studies are in PHASE2, 1 study is in EARLY_PHASE1, 1 study is in PHASE1. The presence of Phase 3 trials indicates that some als treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 78 different organizations, including University of Wisconsin, Madison, University of Southern California, University of Central Florida, HBSA, Centers for Disease Control and Prevention, and 73 others. The large number of sponsors reflects significant research interest and investment in als treatment advancement.
Geographically, als trials are most concentrated in Bethesda, Maryland (14 trials); Chicago, Illinois (13 trials); Birmingham, Alabama (11 trials); San Francisco, California (11 trials); Los Angeles, California (10 trials) and 7 other cities.
Featured ALS Studies
Highlighted recruiting studies for als, selected by enrollment size and research scope.
Enrollment Barriers, Procedural Denials, and Loss of Medicaid Coverage
The goal of this study is to try new outreach methods to improve access to Medicaid for those who lost Medicaid for procedural reasons. The main questions it aims to answer are: 1. How does a live phone call from a Navigator impact Medicaid enrollment among people who lost Medicaid coverage for procedural reasons? 2. What is the effectiveness of outreach using a live call rather than a pre-record...
Alzheimer Prevention Trials (APT) Webstudy
The goal of the Alzheimer Prevention Trials (APT) Webstudy is to accelerate enrollment for Alzheimer's disease (AD) clinical trials by identifying and tracking individuals who may be at higher risk for developing AD dementia.
Contact Registry for Clinical Trials
The purpose of the Contact Registry for Clinical Trials is to develop a database/listserv of persons interested in clinical trials occurring at the University of Central Florida College of Medicine. Sign up for the UCF College of Medicine's Contact Registry for Clinical Trials to learn about clinical research and clinical trials in areas of interest to you! https://ucf.qualtrics.com/jfe/form/SV\...
Frequently Asked Questions About ALS Clinical Trials
Are there als clinical trials near me?
Yes, there are 100 als clinical trials currently recruiting across 167+ cities in the United States, including Bethesda, Maryland; Chicago, Illinois; Birmingham, Alabama. Browse the studies above to find one at a location convenient for you.
How do I join a als clinical trial?
To join a als clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are als clinical trials free?
Yes, participation in als clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of als treatments are being studied?
Current als clinical trials are testing a range of approaches across NA (35 studies), PHASE3 (10 studies), PHASE2 (4 studies), EARLY_PHASE1 (1 study), PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 78 research organizations.
Is it safe to participate in als clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 20, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 20, 2026 · Data from ClinicalTrials.gov