Modulating Exercise Dosage to Improve Concussion Recovery
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required t...
Hyperbaric Oxygen Brain Injury Treatment Trial
The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the ou...
Ketamine, SGB and Combination Treatment for TBI
Post-Traumatic Stress Disorder (PTSD) and traumatic brain injury (TBI) with associated headache are amongst the most common injuries sustained by our deployed forces in Iraq and Afghanistan, as well a...
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone defi...
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms exp...
Novel Intervention for Chronic Complex TBI in OEF/OIF/OND Veterans
The goal of this clinical trial is to compare pregnenolone and placebo (a placebo is a look-alike substance that contains no active drug) in Operation Enduring Freedom/Operation Iraqi Freedom/Operatio...
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem ...
Buspirone and Melatonin for Depression Following Traumatic Brain Injury
Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination. The current research group conduc...
Top Cities for Traumatic Brain Injury Clinical Trials
Traumatic Brain Injury clinical trials are recruiting across 23 cities. Here are the cities with the most active studies:
About Traumatic Brain Injury
Traumatic brain injury (TBI) results from a violent blow or jolt to the head or body that disrupts normal brain function. Effects can range from mild concussions to severe cognitive impairment. Treatment depends on severity and may include rehabilitation, medication, and surgery.
Clinical trials are advancing new treatments for traumatic brain injury. Currently, 8 studies are recruiting a combined 1,078 participants across the United States. Research is being conducted by 8 organizations including University of Colorado, Denver, Hennepin Healthcare Research Institute, Northwestern University and 5 others.
2026 Traumatic Brain Injury Research Landscape
As of March 2026, the traumatic brain injury clinical trial landscape includes 8 actively recruiting studies across 23 cities in the United States. These studies are collectively seeking 1,078 participants, with an average enrollment target of 135 per study.
Research is being led by 8 different organizations, including University of Colorado, Denver, Hennepin Healthcare Research Institute, Northwestern University, VA Office of Research and Development, Foundation for Advancing Veterans' Health Research, and 3 others.
Geographically, traumatic brain injury trials are most concentrated in Durham, North Carolina (3 trials); Boston, Massachusetts (2 trials); Minneapolis, Minnesota (2 trials); Houston, Texas (2 trials); San Antonio, Texas (2 trials) and 7 other cities.
Featured Traumatic Brain Injury Studies
Highlighted recruiting studies for traumatic brain injury, selected by enrollment size and research scope.
Modulating Exercise Dosage to Improve Concussion Recovery
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high d...
Hyperbaric Oxygen Brain Injury Treatment Trial
The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent phase III trial.
Ketamine, SGB and Combination Treatment for TBI
Post-Traumatic Stress Disorder (PTSD) and traumatic brain injury (TBI) with associated headache are amongst the most common injuries sustained by our deployed forces in Iraq and Afghanistan, as well as in more recent conflicts in Eastern Europe and the Middle East. This study aims to determine whether a procedural intervention (stellate ganglion block (SGB)) or medication (ketamine), alone or in c...
Frequently Asked Questions About Traumatic Brain Injury Clinical Trials
Are there traumatic brain injury clinical trials near me?
Yes, there are 8 traumatic brain injury clinical trials currently recruiting across 23+ cities in the United States, including Durham, North Carolina; Boston, Massachusetts; Minneapolis, Minnesota. Browse the studies above to find one at a location convenient for you.
How do I join a traumatic brain injury clinical trial?
To join a traumatic brain injury clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are traumatic brain injury clinical trials free?
Yes, participation in traumatic brain injury clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of traumatic brain injury treatments are being studied?
Current traumatic brain injury clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 8 research organizations.
Is it safe to participate in traumatic brain injury clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 2, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 2, 2026 · Data from ClinicalTrials.gov